Cells Tissues Organs

 

The Influence of Colonizing Micro-Organisms on Development of Crypt Architecture in the Neonatal Mouse Colon

Hill R.R.a · Cowley H.M.b

Author affiliations

Departments of aAnatomy and bMicrobiology University of the Witwatersrand, Johannesburg, South Africa

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Acta Anat 1990;137:137–140

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: May 17, 1989
Accepted: July 03, 1989
Published online: July 16, 2008
Issue release date: 1990

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: https://www.karger.com/CTO

Abstract

The effects of the normal colonizing microflora on postnatal development in the infant mouse were determined by comparison of crypt parameters in histological sections of the ascending colons of conventional specified-pathogen-free mice and their germ-free counterparts. Association of bacteria with the developing colonic mucosa in the third postnatal week caused a lengthening of the crypt column and depressed the total number of secreting goblet cells in each crypt. Thus the increasing bacterial burden during colonization of the developing colon was associated not only with expansion of the proliferative component of the crypt but also with modulation of the relative proportions of crypt cell populations.

© 1990 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: May 17, 1989
Accepted: July 03, 1989
Published online: July 16, 2008
Issue release date: 1990

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: https://www.karger.com/CTO


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