Cells Tissues Organs
Orthogonal Arrays Are Absent from the Membranes of Human Glioblastomatous TissuesHatton J.D. · Sang U H.Division of Neurological Surgery, University of California at San Diego, Calif. and Veterans Administration Medical Center, La Jolla, Calif., USA
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Article / Publication Details
Received: March 20, 1989
Accepted: August 29, 1989
Published online: July 16, 2008
Issue release date: 1990
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)
For additional information: https://www.karger.com/CTO
Abstract
Human astrocytic gliomas were studied with the freeze fracture technique. Orthogonal arrays of particles were noted in the plasma membranes of low-grade astrocytoma tissues. However, no such arrays were found in the plasma membranes of anaplastic glioma or glioblastoma tissues. Gap junctions were rarely seen in the membranes of these higher-grade gliomas; when seen, they consisted of relatively few particles in poorly organized plaques. These plasma membranes were dominated by randomly distributed single particles. These findings constitute aspects of the loss of differentiation in these malignant tumors.
© 1990 S. Karger AG, Basel
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Article / Publication Details
Received: March 20, 1989
Accepted: August 29, 1989
Published online: July 16, 2008
Issue release date: 1990
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)
For additional information: https://www.karger.com/CTO
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