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Original Article

Chromosomal Abnormalities in Couples with Reproductive Disorders

Meza-Espinoza J.P.a · Ortiz Anguiano L.b · Rivera H.c

Author affiliations

aUnidad Academica de Ciencias de la Salud y Tecnologia, Universidad Autonoma de Tamaulipas, Matamoros; bCUCEI-U de G and cDoctorado en Genetica Humana, Universidad de Guadalajara and Instituto Mexicano del Seguro Social, Guadalajara, Mexico

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Gynecol Obstet Invest 2008;66:237–240

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: September 26, 2007
Accepted: May 20, 2008
Published online: July 22, 2008
Issue release date: November 2008

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 2

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: https://www.karger.com/GOI

Abstract

Aim: To determine the prevalence of chromosomal abnormalities in couples with reproductive disorders. Methods: A retrospective study was performed in 939 Mexican couples with reproductive disorders (542 with recurrent fetal loss, 356 with malformed/stillborn children, and 41 with sterility) whose karyotype was established on GTG-banded metaphases. Results: A chromosomal aberration was detected in one partner of 52 couples, including a double translocation carrier; therefore, the prevalence of chromosomally abnormal couples was 5.5%; 31 couples with recurrent fetal loss (31/542, 5.7%), 15 with malformed/stillborn children (15/356, 4.2%), and 6 with sterility (6/41, 14.6%). There were 43 couples with structural rearrangements (29 reciprocal translocations, 10 robertsonian translocations, 2 inversions, 1 insertion, and 1 ring) and 9 with gonosomal aneuploidies. The affected partner was female in 28 (53.8%) and male in 24 (46.2%) couples. In addition, 17 couples (1.8%) with the structural variant inversion 9qh were detected. Conclusion: The prevalence of chromosomal abnormalities found in our sample is consistent with figures described in several populations around the world.

© 2008 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: September 26, 2007
Accepted: May 20, 2008
Published online: July 22, 2008
Issue release date: November 2008

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 2

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: https://www.karger.com/GOI


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