Cells Tissues Organs

Original Paper

Failure to Detect a Second-Generation Effect in Female Mice after Neonatal Treatment with an Estrogen (Diethylstilbestrol)

Forsberg J.-G. · Hailing A.

Author affiliations

Department of Anatomy, University of Lund, Sweden

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Acta Anat 1992;144:103–106

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 27, 1991
Accepted: November 15, 1991
Published online: July 16, 2008
Issue release date: 1992

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: https://www.karger.com/CTO

Abstract

Inbred female mice of the NMRI strain were treated subcutaneously with 5 µg diethylstilbestrol (DES) in olive oil or vehicle only for the first 5 days after birth. One group of DES-treated females was killed at the age of 8-12 weeks, and the uterine cervix and adjacent parts of the vagina and uterine horns prepared for histological studies. In all preparations, the cervical epithelial lining contained regions with heterotopic columnar epithelium (HCE) along 69-100% of the length of the common cervical canal. Ovaries from neonatally DES-treated females were grafted to 8-week-old ovariectomized control hosts and these hosts were mated to control males 2 weeks later. The hosts gave birth to normal-sized litters. The female offspring from these litters had a normal cervical epithelial lining and, in turn, gave birth to normal-sized litters. These results indicate that treatment of neonatal female mice with DES does not affect the female germ cells as far as concerns factors associated with the development of HCE or reduced fertility in the next generation.

© 1992 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 27, 1991
Accepted: November 15, 1991
Published online: July 16, 2008
Issue release date: 1992

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: https://www.karger.com/CTO


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