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Original Report: Laboratory Investigation

Effect of Taurine-Conjugated Ursodeoxycholic Acid on Endoplasmic Reticulum Stress and Apoptosis Induced by Advanced Glycation End Products in Cultured Mouse Podocytes

Chen Y. · Liu C.P. · Xu K.F. · Mao X.D. · Lu Y.B. · Fang L. · Yang J.W. · Liu C.

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Department of Endocrinology, First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China

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Am J Nephrol 2008;28:1014–1022

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Article / Publication Details

Received: February 13, 2008
Accepted: May 29, 2008
Published online: July 23, 2008
Issue release date: October 2008

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: https://www.karger.com/AJN


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Abstract of Original Report: Laboratory Investigation

References

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  2. Drummond K, Mauer M: The early natural history of nephropathy in type 1 diabetes. II. Early renal structural changes in type 1 diabetes. Diabetes 2002;51:1580–1587.
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  4. Chuang PY, Yu Q, Fang W, Uribarri J, He JC: Advanced glycation endproducts induce podocyte apoptosis by activation of the FOXO4 transcription factor. Kidney Int 2007;72:965–976.
  5. Bossy-Wetzel E, Green DR: Caspases induce cytochrome C release from mitochondria by activating cytosolic factors. J Biol Chem 1999;274:17484–17490.
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  16. Heuman DM, Mills AS, McCall J, Hylemon PB, Pandak WM, Vlahcevic ZR: Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile acid salts. In vivo studies in the rat. Gastroenterology 1991;100:201–211.
  17. Xie Q, Khaoustov VI, Chung CC, Sohn J, Krishnan B, Lewis DE, Yoffe B: Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology 2002;36:592–601.
  18. Özcan U, Yilmaz E, Özcan L, Furuhashi M, Vaillancourt E, Smith RO, Görgün CZ, Hotamisligil GS: Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006;313:1137–1140.
  19. Oldfield MD, Bach LA, Forbes JM, Nikolic-Paterson D, McRobert A, Thallas V, Atkins RC, Osicka T, Jerums G, Cooper ME: Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE). J Clin Invest 2001;108:1853–1863.
  20. Mundel P, Reiser J, Zuniga Mejia Borja A, Pavenstadt H, Davidson GR, Kriz W, Zeller R: Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res 1997;236:248–258.
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  22. Shankland SJ: The podocyte’s response to injury: role in proteinuria and glomerulosclerosis. Kidney Int 2006;69:2131–2147.
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Article / Publication Details

Received: February 13, 2008
Accepted: May 29, 2008
Published online: July 23, 2008
Issue release date: October 2008

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: https://www.karger.com/AJN


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