Intervirology
Original Paper
A Mouse Model of Transmural Myocardial Necrosis Due to Coxsackievirus B4: Observations over 12 MonthsKhatib R. · Chason J.L. · Lerner A.M.Department of Medicine, Wayne State University School of Medicine, and Department of Pathology, Henry Ford Hospital, Detroit, Mich., USA
Keywords: Coxsackievirus B4Myocardial necrosis |
|
Log in to MyKarger to check if you already have access to this content.
KAB
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price.
Article / Publication Details
Received: April 14, 1982
Published online: July 24, 2008
Issue release date: 1982
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)
For additional information: https://www.karger.com/INT
Abstract
The course of coxsackievirus B4 necrotizing myocarditis was studied over a 12-month period in 712 ICR Swiss mice inoculated at less than 48 h of age. Affected animals were sacrificed at intervals until 1 year. Microscopically, focal myocardial necrosis, which was often transmural in extent with mixed inflammatory exudate, and subsequent fibrous replacement were induced in 75% of the examined animals. The left ventricle (63 of 69 subjects, 91.3%), interventricular septum (39 of 69 subjects, 56.5%) and right ventricle (26 of 69 subjects, 37.7%) were most frequently involved. Thinning of the ventricular wall and grossly apparent localized ventricular bulges (aneurysms) were seen in 22 subjects (the left ventricle 16 times, the right ventricle 5 times, and the interventricular septum 5 times). Coronary arteries were normal in all instances.
© 1982 S. Karger AG, Basel
Related Articles:
Article / Publication Details
Received: April 14, 1982
Published online: July 24, 2008
Issue release date: 1982
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)
For additional information: https://www.karger.com/INT
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Get Permission