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Original Paper

Influence of CYP11B2 Gene Polymorphism on the Prevalence of Hypertension and the Blood Pressure in Japanese Men: Interaction with Dietary Salt Intake

Song Y.a · Miyaki K.a, b · Araki J.a · Zhang L.a · Takahashi Y.b · Nakayama T.b · Muramatsu M.a

Author affiliations

aDepartment of Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, and bDepartment of Health Informatics, Kyoto University School of Public Health, Kyoto, Japan

Related Articles for ""

J Nutrigenet Nutrigenomics 2008;1:252–258

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 17, 2007
Accepted: May 22, 2008
Published online: August 06, 2008
Issue release date: August 2008

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1661-6499 (Print)
eISSN: 1661-6758 (Online)

For additional information: http://www.karger.com/JNN

Abstract

Aims: CYP11B2 gene encodes a key enzyme for the production of aldosterone. Our aim is to investigate the association of –344T/C polymorphism with hypertension in Japanese men. The interaction between genotypes and dietary salt intake was also considered. Methods: Three hundred and ten Japanese male workers participated in this study. Daily salt intake was calculated from a food frequency questionnaire. Melting curve analysis was used to determine CYP11B2 genotypes. Results:There was a significant association between the CT + TT genotype and higher prevalence of hypertension (odds ratio: 3.03; p = 0.014). The association presented in a recessive manner and was strongest in the high-salt intake group (odds ratio: 9.44; p = 0.049). Only in the high-intake group, systolic blood pressure (SBP) was significantly higher in the CT + TT group than in the CC group (p = 0.038). The SBP had a positive correlation with salt intake in the CT + TT group (p for linear trend = 0.021), but not in the CC group (p for interaction = 0.011). Conclusions: CYP11B2 gene –344C/T polymorphism affects the risk of hypertension in Japanese men and high-salt intake levels strengthen this association. This gene-diet interaction warrants further study to elucidate the efficacy of salt restriction as an antihypertensive therapy in different genotypes.

© 2008 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 17, 2007
Accepted: May 22, 2008
Published online: August 06, 2008
Issue release date: August 2008

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1661-6499 (Print)
eISSN: 1661-6758 (Online)

For additional information: http://www.karger.com/JNN


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