Enhancement of the Antibiotic Activity against a Multiresistant Escherichia coli by Mentha arvensis L. and ChlorpromazineCoutinho H.D.M.a · Costa J.G.M.a · Lima E.O.b · Falcão-Silva V.S.c · Siqueira-Júnior J.P.c
aLaboratory of Research in Natural Products, Department of Physical and Biological Sciences, Center of Biological Sciences and Health, University of the Region of Cariri, Crato; bLaboratory of Mycology, Department of Pharmaceutical Sciences, Center of Health Sciences and cLaboratory of Genetics of Microorganisms, Department of Molecular Biology, Center of Exact and Natural Sciences, Federal University of Paraíba, João Pessoa, Brazil
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
Article / Publication Details
Background: This is the first report testing the antibiotic resistance-modifying activity of Mentha arvensis. Methods: In this study an ethanol extract of M. arvensis L. and chlorpromazine were tested for their antimicrobial activity alone or in combination with conventional antibiotics against strains of Escherichia coli. Results: The growth of two E. coli strains tested was not inhibited by the extract. The minimum inhibitory concentration and minimal bactericide concentration values were ≧1 mg/ml for both strains of E. coli used. A potentiating effect of this extract on gentamicin was demonstrated. Similarly, there was a potentiating effect of chlorpromazine on kanamycin, amikacin and tobramycin, indicating the involvement of an efflux system in the resistance to these aminoglycosides. Conclusions: It is therefore suggested that extracts from M. arvensis could be used as a source of plant-derived natural products with resistance-modifying activity, such as in the case of gentamicin, constituting a new weapon against bacterial resistance to antibiotics, as with chlorpromazine.
© 2008 S. Karger AG, Basel
- Lu Y, Zhao YP, Wang ZC, Chen SY, Fu CX: Composition and antimicrobial activity of the essential oil of Actinidia macrosperma from China. Nat Prod Res 2007;21:227–233.
- Mbwambo ZH, Moshi MJ, Masimba PJ, Kapingu MC, Nondo RS: Antimicrobial activity and brine shrimp toxicity of extracts of Terminalia brownii roots and stem. BMC Complement Altern Med 2007;7:9.
- Singh G, Maurya S, Delampasona MP, Catalan CA: A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents. Food Chem Toxicol 2007;45:1650–1661.
- Senatore F, Rigano D, Formisano C, Grassia A, Basile A, Sorbo S: Phytogrowth-inhibitory and antibacterial activity of Verbascum sinuatum. Fitoterapia 2007;78:244–247.
- Benoit-Vical F, Grellier P, Abdoulaye A, Moussa I, Ousmane A, Berry A, Ikhiri K, Poupat C: In vitro and in vivo antiplasmodial activity of Momordica balsamina alone or in a traditional mixture. Chemotherapy 2006;52:288–292.
- Gurib-Fakim A: Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol Aspects Med 2006;27:1–93.
- Gibbons S: Anti-staphylococcal plant natural products. Nat Prod Rep 2004;21:263–277.
- Wolfart K, Spengler G, Kawase M, Motohashi N, Molnar J, Viveiros M, Amaral L: Interaction between 3,5-diacetyl-1,4-dihydropyridines and ampicillin, and erythromycin on different E. coli strains. In Vivo 2006;20:367–372.
- Molnar J, Molnar A, Spengler G, Mandi Y: Infectious plasmid resistance and efflux pump mediated resistance. Acta Microbiol Immunol Hung 2004;51:333–349.
- Wannissorn B, Jarikasem S, Siriwangchai T, Thubthimthed S: Antibacterial properties of essential oils from Thai medicinal plants. Fitoterapia 2005;76:233–236.
- Duarte MC, Figueira GM, Sartoratto A, Rehder VL, Delarmelina C: Anti-Candida activity of Brazilian medicinal plants. J Ethnopharmacol 2005;97:305–311.
- Jana S, Deb JK: Molecular understanding of aminoglycoside action and resistance. Appl Microbiol Biotechnol 2006;70:140–150.
- Smith E, Williamson M, Wareham N, Kaatz G, Gibbons S: Antibacterials and modulators of bacterial resistance from the immature cones of Chamaecyparis lawsoniana. Phytochemistry 2007;68:210–217.
Coutinho HDM, Cordeiro LN, Bringel KP: Antibiotic resistance of pathogenic bacteria isolated from the population of Juazeiro do Norte – Ceará. R Bras Ci Saúde2005;9:127–138.
Brasileiro BG, Pizziolo VR, Raslan DS, Jamal CM, Silveira D: Antimicrobial and cytotoxic activities screening of some Brazilian medicinal plants used in Governador Valadares district. Rev Bras Cienc Farm 2006;42:195–202.
- Javadpour MM, Juban MM, Lo WC, Bishop SM, Alberty JB, Cowell SM, Becker JM, McLaughlin ML: De novo antimicrobial peptides with low mammalian cell toxicity. J Med Chem 1996;39:3107–3113.
- Prabuseenivasan S, Jayakumar M, Ignacimuthu S: In vitroantibacterial activity of some plant essential oils. BMC Complement Altern Med 2006;6:39.
- Houghton PJ, Howes MJ, Lee CC, Steventon G: Uses and abuses of in vitro tests in ethnopharmacology: visualizing an elephant. J Ethnopharmacol 2007;110:391–400.
- Romero-Jiménez M, Campos-Sánchez J, Analla M, Muñoz-Serrano A, Alonso-Moraga A: Genotoxicity and anti-genotoxicity of some traditional medicinal herbs. Mutat Res 2005;585:147–155.
- Schelz Z, Molnar J, Hohmann J: Antimicrobial and antiplasmid activities of essential oils. Fitoterapia 2006;77:279–285.
- Rafii F, Shahverdi AR: Comparison of essential oils from three plants for enhancement of antimicrobial activity of nitrofurantoin against Enterobacteria. Chemotherapy 2007;53:21–25.
- Shin TY: Inhibition of immunologic and nonimmunologic stimulation-mediated anaphylactic reactions by the aqueous extract of Mentha arvensis. Immunopharmacol Immunotoxicol 2003;25:273–283.
- Kristiansen JE, Amaral L: The potential management of resistant infections with non-antibiotics. J Antimicrob Chemother 1997;40:319–327.
- McMurry L, Petrucci RE, Levy SB: Active efflux of tetracycline encoded by four genetically different tetracycline resistance determinants in Escherichia coli. Proc Natl Acad Sci USA 1980;77:3974–3977.
- Van Bambeke F, Glupczynski Y, Plesiat P, Pechere JC, Tulkens PM: Antibiotic efflux pumps in prokaryotic cells: occurrence, impact on resistance and strategies for the future of antimicrobial therapy. J Antimicrob Chemother 2003;51:1055–1065.
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.