Nephron Clinical Practice
Original Paper
Calcium Requirements after Parathyroidectomy in Patients with Refractory Secondary HyperparathyroidismViaene L. · Evenepoel P. · Bammens B. · Claes K. · Kuypers D. · Vanrenterghem Y.Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
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Article / Publication Details
Received: February 19, 2008
Accepted: May 30, 2008
Published online: September 01, 2008
Issue release date: November 2008
Number of Print Pages: 1
Number of Figures: 1
Number of Tables: 3
eISSN: 1660-2110 (Online)
For additional information: https://www.karger.com/NEC
Abstract
Background/Aims: Calcium supplements are often required following successful parathyroidectomy (PTX) in order to prevent overt hypocalcemia. The current study aims to quantify these calcium needs and to identify predictors of a high calcium need present at the time of surgery. Methods: Charts of 42 patients with chronic kidney disease stage 5D, who underwent a successful subtotal PTX, were reviewed in detail. Biochemical indices of mineral metabolism available within a time frame of 4 weeks before and 6 weeks after the surgery were registered. Details concerning active vitamin D (1-α-calcidiol and calcitriol) and calcium supplementation were recorded as well. Results: Serum calcium, phosphorus and PTH levels declined whereas total alkaline phosphatase levels increased significantly in the early post-PTX period. Transient hypocalcemia was observed in 83% of the patients. The median daily postoperative elemental calcium requirements amounted to 3.2 g during week 1, and declined to 2.4 g during week 6. A high preoperative PTH level and a low serum calcium level were identified as independent predictors of a high postoperative calcium need. Conclusion: Substantial amounts of elemental calcium are required following successful subtotal PTX in order to avoid frank hypocalcemia, especially in patients with a high PTH level and a low calcium level before surgery.
© 2008 S. Karger AG, Basel
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Article / Publication Details
Received: February 19, 2008
Accepted: May 30, 2008
Published online: September 01, 2008
Issue release date: November 2008
Number of Print Pages: 1
Number of Figures: 1
Number of Tables: 3
eISSN: 1660-2110 (Online)
For additional information: https://www.karger.com/NEC
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