Human Heredity
A General Model for the Genetic Analysis of Pedigree DataElston R.C. · Stewart J.Department of Biostatistics and the Genetics Curriculum, University of North Carolina, Chapel Hill, N. C, and Department of Genetics, Milton Road, Cambridge
Keywords: Pedigree dataGenetic analysis |
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Article / Publication Details
Published online: August 27, 2008
Issue release date: 1971
Number of Print Pages: 20
Number of Figures: 0
Number of Tables: 0
ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)
For additional information: https://www.karger.com/HHE
Abstract
Assuming random mating and random sampling of pedigrees, the likelihood of a set of pedigree data is developed in terms of: (1) the population distribution of the different genotypes; (2) the phenotypic distributions for the different genotypes, and (3) the genotypic distribution of offspring given the parents’ genotypes. This last is given for any number of unlinked autosomal loci, two linked autosomal loci, an X-linked locus, and combinations of these possibilities. Methods are given for using this likelihood to test specific genetic hypotheses and for genetic counselling.
© 1971 S. Karger AG, Basel
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Article / Publication Details
Published online: August 27, 2008
Issue release date: 1971
Number of Print Pages: 20
Number of Figures: 0
Number of Tables: 0
ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)
For additional information: https://www.karger.com/HHE
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