Human Heredity
Extensions to Pedigree AnalysisI. Likelihood Calculations for Simple and Complex Pedigrees Department of Biomathematics, University of California, Los Angeles, Calif., and Department of Biostatistics, the Genetics Curriculum and the Biological Sciences Research Center, University of North Carolina, Chapel Hill, N.C.
Keywords: Pedigree analysisGraphsLikelihoods |
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Article / Publication Details
Published online: August 28, 2008
Issue release date: 1975
Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0
ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)
For additional information: https://www.karger.com/HHE
Abstract
A graph theoretic definition of pedigrees is given and a distinction drawn between simple and complex pedigrees. Algorithms are presented to calculate the likelihood of any kind of pedigree, assuming only segregation at a finite set of loci, nonassortative mating and no environmental correlations; multiple births and consanguineous marriages are explicitly allowed for. The formulation given can lead to more powerful genetic counselling, segregation analysis and linkage analysis.
© 1975 S. Karger AG, Basel
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Article / Publication Details
Published online: August 28, 2008
Issue release date: 1975
Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0
ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)
For additional information: https://www.karger.com/HHE
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