Human Heredity

 

Extensions to Pedigree Analysis

I. Likelihood Calculations for Simple and Complex Pedigrees

Lange K. · Elston R.C.

Author affiliations

Department of Biomathematics, University of California, Los Angeles, Calif., and Department of Biostatistics, the Genetics Curriculum and the Biological Sciences Research Center, University of North Carolina, Chapel Hill, N.C.

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Hum Hered 1975;25:95–105

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: August 28, 2008
Issue release date: 1975

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: https://www.karger.com/HHE

Abstract

A graph theoretic definition of pedigrees is given and a distinction drawn between simple and complex pedigrees. Algorithms are presented to calculate the likelihood of any kind of pedigree, assuming only segregation at a finite set of loci, nonassortative mating and no environmental correlations; multiple births and consanguineous marriages are explicitly allowed for. The formulation given can lead to more powerful genetic counselling, segregation analysis and linkage analysis.

© 1975 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: August 28, 2008
Issue release date: 1975

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: https://www.karger.com/HHE


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