Human Heredity

Original Paper

Problems in Estimating Non-Disjunction Rate from the F-Bodies of Two-Headed Human Spermatozoa

Beatty R.A.

Author affiliations

ARC Unit of Animal Genetics, Department of Genetics, University of Edinburgh, Edinburgh

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Hum Hered 1978;28:335–340

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: August 28, 2008
Issue release date: 1978

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: https://www.karger.com/HHE

Abstract

The F-bodies of two-headed human spermatozoa offer a unique potential for estimating non-disjunction rate of the Y chromosome. But there is an unexplained quantitative discrepancy: a gross deficiency of two-headed spermatozoa with no F-bodies, relative to the numbers with one F-body in each head. Any estimation of non-disjunction rate would be overshadowed by this and other major factors. Two-headed spermatozoa cannot be regarded as a random aggregation of haploid heads in pairs. DNA measurements confirmed that each head of 25 normal-sized two-headed spermatozoa was haploid. The distribution of F-body classes is independent of whether sperm tails are single or double. Donors with an exceptionally high incidence of two-headed spermatozoa exist.

© 1978 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: August 28, 2008
Issue release date: 1978

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

For additional information: https://www.karger.com/HHE


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