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M31, a murine homolog of Drosophila HP1, is concentrated in the XY body during spermatogenesis

Motzkus D.a · Singh P.B.b · Hoyer-Fender S.a

Author affiliations

aUniversität Göttingen, III. Zoologisches Institut-Entwicklungsbiologie, Göttingen (Germany), and bDivision of Integrative Biology, The Roslin Institute, Edinburgh, Midlothian, Scotland (UK)

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Cytogenet Cell Genet 86:83–88 (1999)

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: September 02, 1999
Issue release date: 1999

Number of Print Pages: 6
Number of Figures: 5
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR

Abstract

Abstract.

The formation of the sex vesicle, or XY body, during male meiosis and pairing of the sex chromosomes are thought to be essential for successful spermatogenesis. Despite its cytological discovery a century ago, the mechanism of XY body formation, particularly heterochromatinization of the sex chromosomes, has remained unclear. The HP1 class of chromobox genes are thought to encode proteins involved in the packaging of chromosomal DNA into repressive heterochromatin domains, as seen, for example, in position-effect variegation. Study of the distribution of a murine HP1-like chromodomain protein, M31, during spermatogenesis revealed spreading from the tip of the XY body in mid-stage pachytene spermatocytes to include the whole of the XY body in late-pachytene spermatocytes. We also demonstrate that the formation of the XY body during spermatogenic progression in neonatal mice coincides with the expression of a novel nuclear isoform of M31, M31p21. These results support the view that a common mechanistic basis exists for heterochromatin-induced repression, homeotic gene silencing, and sex-chromosome inactivation during mammalian spermatogenesis.


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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: September 02, 1999
Issue release date: 1999

Number of Print Pages: 6
Number of Figures: 5
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR


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