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cDNA cloning, characterization and chromosome mapping of the gene encoding human cartilage associated protein (CRTAP)

Tonachini L.a · Morello R.a · Monticone M.a · Skaug J.b · Scherer S.W.b · Cancedda R.a,c · Castagnola P.a

Author affiliations

aIstituto Nazionale per la Ricerca sul Cancro, Centro di Biotecnologie Avanzate, Genova (Italy); bDepartment of Genetics, Research Institute, The Hospital for Sick Children, Toronto, Ontario (Canada); cDipartimento Oncologia, Biologia e Genetica, Università di Genova (Italy)

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Cytogenet Cell Genet 87:191–194 (1999)

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: February 18, 2000
Issue release date: 1999

Number of Print Pages: 4
Number of Figures: 5
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR

Abstract

Abstract.

We have recently isolated and characterized cDNA clones coding for a novel developmentally regulated avian and mouse embryo protein, CASP for Cartilage Associated Protein. Here we describe the isolation and characterization of the gene coding for the human CASP. The comparison of the putative human and mouse protein sequences with the chick sequence revealed an overall high identity (89% and 51%, respectively). Homology search with known DNA and protein sequences showed that CASPs are related to two mammalian nuclear proteins. Here we demonstrate definitively that CASPs are distinct from these nuclear proteins. However, sequence comparison analyses suggest that all of these proteins belong to a new family. In all human tissues examined two CASP mRNA species were detected, whereas a single mRNA and three mRNAs were found in chick and mouse, respectively. The human CASP gene (CRTAP) was assigned to chromosome 3p22 by fluorescence in situ hybridization.   

© 2000 S. Karger AG, Basel


References

  1. Castagnola P, Gennari M, Morello R, Tonachini L, Marin O, Gaggero A, Cancedda R: Cartilage Associated (CASP) is a novel developmentally regulated chick embryo protein. J Cell Sci 110:1351–1359 (1997).
    External Resources
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  6. Morello R, Tonachini L, Monticone M, Viggiano L, Rocchi M, Cancedda R, Castagnola P: cDNA cloning, characterization and chromosome mapping of Crtap encoding the mouse Cartilage Associated Protein. Matrix Biol 18:319–324 (1999).
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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: February 18, 2000
Issue release date: 1999

Number of Print Pages: 4
Number of Figures: 5
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR


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