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Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12

Ardley H.C.a · Rose S.A.a · Tan N.a · Leek J.P.a · Markham A.F.a · Robinson P.A.a,b

Author affiliations

aMolecular Medicine Unit and bLeeds Dental Institute, University of Leeds, St. James’s University Hospital, Leeds (UK)

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Cytogenet Cell Genet 89:137–140 (2000)

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: June 26, 2000
Issue release date: 2000

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR

Abstract

Abstract.

The human UBE2L6 gene encodes UbcH8Kumar, a ubiquitin-conjugating enzyme (E2) highly simliar in primary structure to UbcH7 which is encoded by UBE2L3. Like UBC4 and UBC5 in yeast, these proteins demonstrate functional redundancy. Herein we report the intron/exon structure of UBE2L6. Comparison of the genomic organization of UBE2L6 with UBE2L3 demonstrates that these genes remain highly conserved at the genomic as well as at the protein level. We also describe the chromosomal localization of UBE2L6, which maps to chromosome 11q12.    

© 2000 S. Karger AG, Basel


References

  1. Ardley HC, Moynihan TP, Thompson J, Leek JP, Markham AF, Robinson PA: Rapid isolation of genomic clones for individual members of human multigene families: Identification and localisation of UBE2L4, a novel member of a ubiquitin conjugating enzyme dispersed gene family. Cytogenet Cell Genet 79:188–192 (1997).
    External Resources
  2. Harbers K, Muller U, Grams A, Li E, Jaenisch R, Franz, T: Provirus integration into a gene encoding a ubiquitin-conjugating enzyme results in a placental defect and embryonic lethality. Proc natl Acad Sci, USA 93:12412–12417 (1996).
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  6. Moynihan TP, Ardley HC, Leek JP, Thompson J, Brindle NS, Markham AF, Robinson PA: Characterization of a human ubiquitin-conjugating enzyme gene, UBE2L3. Mammal Genome 7:520–525 (1996).
  7. Moynihan TP, Cole CG, Dunham I, Markham AF, Robinson PA: Fine-mapping, genomic structure determination, and transcript analysis of the human ubiquitin-conjugating enzyme gene UBE2L3. Genomics 51:124–127 (1998).
  8. Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Scheffner M, Markham AF, Robinson PA: RING finger and IBR motifs characterize the interaction domains of HHARI and H7-AP1 with the ubiquitin-conjugating enzymes UbcH7 and UbcH8. J biol Chem 274:30963–30968 (1999).
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  10. Robinson PA, Leek JP, Thompson J, Carr IM, Bailey A, Moynihan TP, Coletta PL, Lench NJ, Markham AF: A human ubiquitin-conjugating enzyme, L-UBC, maps in the Alzheimer’s disease locus on chromosome 14q24.3. Mammal Genome 6:725–731 (1995).
    External Resources
  11. Scheffner M, Huibregtse JM, Howley PM: Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53. Proc natl Acad Sci, USA 91:8797–8801 (1994).

Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: June 26, 2000
Issue release date: 2000

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR


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