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Expression and comparative chromosomal mapping of MKP-5 genes DUSP10/Dusp10

Masuda K.a · Shima H.a · Kikuchi K.a · Watanabe Y.b · Matsuda Y.b,c

Author affiliations

aDivision of Biochemical Oncology and Immunology, Institute for Genetic Medicine, Hokkaido University; bChromosome Research Unit, Faculty of Science, and cLaboratory of Cytogenetics, Division of Bioscience, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo (Japan)

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Cytogenet Cell Genet 90:71–74 (2000)

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: October 06, 2000
Issue release date: 2000

Number of Print Pages: 4
Number of Figures: 3
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR

Abstract

Abstract.

We have isolated a mouse cDNA for a novel MAPK phosphatase, designated as MKP-5. Two MKP-5 mRNA transcripts of 3.5 kb and 2.7 kb were detected. The 3.5-kb transcript was expressed in almost all the tissues examined, and was particularly abundant in cerebellum, skeletal muscle, and bone marrow. On the other hand, the 2.7-kb transcript was specifically and highly expressed in testis. The MKP-5 genes (DUSP10/Dusp10) were localized to chr 1q41, Chr 1H5 and chr 13q26 in human, mouse and rat, respectively. They were mapped in regions where conserved linkage homology has been identified among the three species.   

© 2000 S. Karger AG, Basel


References

  1. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analyt Biochem 162:156–159 (1987).
  2. Davis RJ: MAPKs: new JNK expands the group. Trends Biochem Sci 19:470–473 (1994).
  3. Evans EP: Standard G-banded Karyotype, in Lyon MF, Rastan S, Brown SDM (eds): Genetic Variants and Strains of the Laboratory Mouse, pp1446–1448 (Oxford University Press, Oxford 1996).
  4. Furukawa T, Yatsuoka T, Youssef EM, Abe T, Yokoyama T, Fukushige S, Soeda E, Hoshi M, Hayashi Y, Sunamura M, Kobari M, Horii A: Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer. Cytogenet Cell Genet 82:156–159 (1998)
  5. Haneda M, Sugimoto T, Kikkawa R: Mitogen-activated protein kinase phosphatase: a negative regulator of the mitogen-activated protein kinase cascade. Eur J Pharmacol 15; 365:1–7 (1999).
  6. ISCN (1985): An International System for Human Cytogenetic Nomenclature, Harnden DG, Klinger HP (eds) ( S Karger, Basel 1985).
  7. Keyse SM, Ginsburg M: Amino acid sequence similarity between CL100, a dual-specificity MAP kinase phosphatase and cdc25. Trends Biochem Sci 18:377–378 (1993).
  8. Keyse SM: An emerging family of dual specificity MAP kinase phosphatases. Biochim biophys Acta 1265:152–160 (1995).
    External Resources
  9. Kyriakis JM, Avruch J: Protein kinase cascades activated by stress and inflammatory cytokines. Bioessays 18:567–577 (1996).
  10. Matsuda Y, Chapman VM: Application of fluorescence in situ hybridization in genome analysis of the mouse. Electrophoresis 16:261–272 (1995).
  11. Matsuda Y, Harada Y-N, Natsuume-Sakai S, Lee K, Shiomi T, Chapman VM: Location of the mouse complement factor H gene (cfh) by FISH analysis and replication R-banding. Cytogenet Cell Genet 61:282–285 (1992).
  12. Nakamura K, Shima H, Watanabe M, Haneji T, Kikuchi K: Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis. Biochem J 344:819–825 (1999).
  13. Nishida E, Gotoh Y: The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem Sci 18:128–131 (1993).
  14. Satoh H, Yoshida MC, Sasaki M: High resolution chromosome banding in the Norway rat, Rattus norvegicus. Cytogenet Cell Genet 50:151–154 (1989).
    External Resources
  15. Serikawa T, Cui Z, Yokoi N, Kuramoto T, Kondo Y, Kitada K, Guénet J-L: A comparative genetic map of rat, mouse and human genomes. Exp Anim 47:1–9 (1998).
  16. Smith A, Price C, Cullen M, Muda M, King A, Ozanne B, Arkinstall S, Ashworth A: Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7). Genomics 42:524–527 (1997).
    External Resources
  17. Somssich IE, Hameister H: Standard karyotype of early replicating bands (RBG-banding), in Lyon MF, Rastan S, Brown SDM (eds): Genetic Variants and Strains of the Laboratory Mouse, pp 1450–1451 (Oxford University Press, Oxford 1996).
  18. Takahashi E, Hori T, O’Connell P, Leppert M, White R: R-banding and nonisotopic in situ hybridization: precise localization of the human type II collagen gene (COL2A1). Hum Genet 86:14–16 (1990).
  19. Tanoue T, Moriguchi T, Nishida E: Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. J biol Chem 274:19949–19956 (1999).
  20. Yokoyama A, Karasaki H, Urushibara N, Nomoto K, Imai Y, Nakamura K, Mizuno Y, Ogawa K, Kikuchi K: The characteristic gene expressions of MAPK phosphatases 1 and 2 in hepatocarcinogenesis, rat ascites hepatoma cells, and regenerating rat liver. Biochem biophys Res Commun 239:746–751 (1997).

Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: October 06, 2000
Issue release date: 2000

Number of Print Pages: 4
Number of Figures: 3
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR


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