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Review Article · Übersichtsarbeit

Free Access

Critical Appraisal of Randomized Clinical Trials: Can We Have Faith in the Conclusions?

Mittlböck M.

Author affiliations

Core Unit for Medical Statistics and Informatics, Section of Clinical Biometrics, Medical University of Vienna, Austria

Corresponding Author

Prof. Dr. Martina Mittlböck, Core Unit for Medical Statistics and Informatics, Section of Clinical Biometrics, Medical University of Vienna, Spitalgasse 23, 1090 Wien, Austria, Tel. +43 1 40400-2276, Fax -6687, martina.mittlboeck@meduniwien.ac.at

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Breast Care 2008;3:341–346

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Abstract

Randomized clinical trials (RCTs) are the most appropriate research design for studying the effectiveness of a specific intervention. Its results are considered as the highest ‘level of evidence’. Published reports on RCTs have already succeeded in a peer review process, but still there can be undetected major deficiencies of the study that may question the reported outcome. It is still up to the readers to assess the quality of publications and to question if the published results apply to their patients. The major points of such a critical appraisal process are reviewed and discussed with a focus on breast cancer studies.

© 2008 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Review Article · Übersichtsarbeit

Published online: October 16, 2008
Issue release date: November 2008

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 1

ISSN: 1661-3791 (Print)
eISSN: 1661-3805 (Online)

For additional information: https://www.karger.com/BRC


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