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Original Article

Influence of Partial Sleep Deprivation on Energy Balance and Insulin Sensitivity in Healthy Women

Bosy-Westphal A.a · Hinrichs S.a · Jauch-Chara K.b · Hitze B.a · Later W.a · Wilms B.a,b · Settler U.a · Peters A.b · Kiosz D.a · Müller M.J.a

Author affiliations

a Institut für Humanernährung und Lebensmittelkunde, Christian-Albrechts-University Kiel, bDepartment of Internal Medicine I, University of Lübeck, Germany

Corresponding Author

Prof. Dr. med. Manfred J. Müller, Institut für Humanernährung und Lebensmittelkunde, Christian-Albrechts-Universität zu Kiel, Düsternbrooker Weg 17, 24105 Kiel, Germany, Tel. +49 43188056-70, Fax -79, mmueller@nutrfoodsc.uni-kiel.de

Related Articles for ""

Obes Facts 2008;1:266–273

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Background: Voluntary sleep restriction is a lifestyle feature of modern societies that may contribute to obesity and diabetes. The aim of the study was to investigate the impact of partial sleep deprivation on the regulation of energy balance and insulin sensitivity. Subjects and Methods: In a controlled intervention, 14 healthy women (age 23–38 years, BMI 20.0–36.6 kg/m2) were investigated after 2 nights of >8 h sleep/night (T0), after 4 nights of consecutively increasing sleep curtailment (7 h sleep/ night, 6 h sleep/night, 6 h sleep/night and 4 h sleep/night; T1) and after 2 nights of sleep recovery (>8 h sleep/night; T2). Resting and total energy expenditure (REE, TEE), glucose-induced thermogenesis (GIT), physical activity, energy intake, glucose tolerance and endocrine parameters were assessed. Results: After a decrease in sleep du-ration, energy intake (+20%), body weight (+0.4 kg), leptin / fat mass (+29%), free triiodothyronine (+19%), free thyroxine (+10%) and GIT (+34%) significantly increased (all p < 0.05). Mean REE, physical activity, TEE, oral glucose tolerance, and ghrelin levels remained unchanged at T1. The effect of sleep loss on GIT, fT3 and fT4 levels was inversely related to fat mass. Conclusion: Short-term sleep deprivation increased energy intake and led to a net weight gain in women. The effect of sleep restriction on energy expenditure needs to be specifically addressed in future studies using reference methods for total energy expenditure.

© 2008 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Article

Published online: October 23, 2008
Issue release date: October 2008

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 2

ISSN: 1662-4025 (Print)
eISSN: 1662-4033 (Online)

For additional information: http://www.karger.com/OFA

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