Pathobiology
Symposium
Ferritin Gene Expression in Health and MalignancyBomford A.B.a · Munro H.N.baLiver Unit, King’s College, School of Medicine and Dentistry, Denmark Hill, London, UK; bUSDA Human Nutrition Center on Aging at Tufts, Boston, Mass., USA
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Article / Publication Details
Received: July 25, 1990
Accepted: August 01, 1990
Published online: October 07, 2008
Issue release date: 1992
Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0
ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)
For additional information: https://www.karger.com/PAT
Abstract
Intracellular iron can be stored in the protein shell of ferritin to protect the cell against the toxic action of the iron. In response to increased cell iron, more ferritin subunits are synthesized using translational and transcriptional mechnisms. Translational control involves a unique stem-loop structure in the 5’ untranslated region of the subunit messengers. When iron level is low, a protein binds to this stem-loop structure and prevents translation. When intracellular iron level rises, the repressor protein is discharged and the large population of messengers begins to translate subunits. Similar stem-loop motifs occur in the 3’ untranslated region of the transferrin receptor messenger where they regulate breakdown of the receptor mRNA. Finally, the presence of excess iron preferentially stimulates transcription of more ferritin message of one type (L-mRNA) which produces ferritin shells favoring iron storage. In this way, protection of the cell against iron excess is enhanced by coordinate changes in rate of synthesis of ferritin mRNA of the L-type, by release of ferritin mRNA stored in the cytoplasm, and by a reduction in the number of receptors for accepting iron into the cell. The application of these principles with reference to malignant cells is discussed.
© 1992 S. Karger AG, Basel
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Article / Publication Details
Received: July 25, 1990
Accepted: August 01, 1990
Published online: October 07, 2008
Issue release date: 1992
Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0
ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)
For additional information: https://www.karger.com/PAT
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