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Original Paper

Urinary Calcium Excretion at Extremes of Sodium Intake in Normal Man

McCarron D.A. · Rankin L.I. · Bennett W.M. · Krutzik S. · McClung M.R. · Luft F.C.

Author affiliations

Division of Nephrology, University of Oregon Health Sciences Center, Portland, Oreg., USA; Division of Nephrology, Indiana University Medical Center, Indianapolis, Ind., USA

Related Articles for ""

Am J Nephrol 1981;1:84–90

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 27, 1980
Accepted: January 20, 1981
Published online: October 22, 2008
Issue release date: 1981

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: https://www.karger.com/AJN

Abstract

To elucidate the relationship between the renal regulation of sodium and calcium excretion at extremes of sodium intake, we studied 6 normal men ingesting a fixed, 400 mg/day calcium intake and four levels of sodium intake from 10 to 1,500 mEq/day. Serum ionized calcium was not influenced by sodium intake. Blood pressure and cardiac index increased modestly. Urinary calcium excretion increased to 262 ± 53 mg/day (mean ± SE). Plasma norepinephrine concentration, serum PTH levels, hematocrit, total serum protein concentrations and CO2 content decreased with increasing sodium intake. Urinary cAMP increased as sodium intake was raised from 10 to 300 mEq/day, but subsequently decreased to basal values. Urinary calcium and sodium excretion were related (p < 0.001) in a nonlinear fashion as were the fractional excretions of these cations (p < 0.001). The filtered calcium load and the fractional calcium excretion were directly and linearly related (p < 0.001). We conclude that the effect of sodium intake on urinary calcium excretion principally reflects changes in the filtered calcium load rather than changes in renal sodium handling. Calcium homeostasis at extremes of sodium intake does not appear to be critically dependent upon PTH-mediated mechanisms. The data suggest that the proximal tubule has a remarkable capacity to dissociate calcium resorption from that of sodium.

© 1981 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: November 27, 1980
Accepted: January 20, 1981
Published online: October 22, 2008
Issue release date: 1981

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: https://www.karger.com/AJN


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