American Journal of Nephrology
Original Paper
Disturbances in the Hypothalamic-Pituitary-Gonadal Axis in Male Patients with Acute Renal FailureLevitan D. · Moser S.A. · Goldstein D.A. · Kletzky O.A. · Lobo R.A. · Massry S.G.Division of Nephrology, Department of Medicine and Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles, Calif, USA
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Article / Publication Details
Received: June 05, 1982
Accepted: January 03, 1983
Published online: October 22, 2008
Issue release date: 1984
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)
For additional information: https://www.karger.com/AJN
Abstract
The function of the hypothalamic-pituitary-gonadal (HPG) axis was examined in 20 male patients with acute renal failure. During the oliguric phase of the disease, the serum concentrations of follicle stimulating hormone (FSH) and total and unbound testosterone were markedly reduced, those of prolactin were elevated while those of luteinizing hormone (LH) were normal. The serum concentrations of sex hormone binding globulin were normal. During the diuretic phase of the illness, the serum levels of FSH and testosterone remained low but those of prolactin fell towards normal. After recovery of renal function, the abnormalities in the serum concentrations of these hormones were reversed. The responses of LH and FSH to gonadotropin releasing hormone and of prolactin to thyrotropin releasing hormone were abnormal and became normal after recovery of renal function. The results demonstrate that: (1) abnormalities in HPG axis occur early in the course of acute renal failure; (2) many features of these derangements are similar to those seen in chronic renal failure, and (3) the alterations in the function of the HPG axis are reversible when renal function is restored. The data suggest that loss of renal function, uremia per se and/or a metabolic consequence of uremia such as secondary hyperparathyroidism are responsible for these derangements.
© 1984 S. Karger AG, Basel
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Article / Publication Details
Received: June 05, 1982
Accepted: January 03, 1983
Published online: October 22, 2008
Issue release date: 1984
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)
For additional information: https://www.karger.com/AJN
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