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Original Paper

Stability of Gentamicin and Tobramycin in Concentrate Solutions for Automated Peritoneal Dialysis

Nance K.S.a · Matzke G.R.b

Author affiliations

aCollege of Pharmacy, Xavier University of Louisiana, New Orleans, La.; bDrug Evaluation Unit, Regional Kidney Disease Program, Hennepin County Medical Center, and College of Pharmacy, University of Minnesota, Minneapolis, Minn., USA

Related Articles for ""

Am J Nephrol 1984;4:240–243

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 03, 1983
Accepted: May 26, 1983
Published online: October 22, 2008
Issue release date: 1984

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: https://www.karger.com/AJN

Abstract

Stability of gentamicin and tobramycin in 30 and 50% dextrose peritoneal dialysate concentrate (PDC) fluids was determined at room temperature. All solutions were prepared and stored at 23 °C and aliquots were obtained at 0, 1, 2, 4, 8, 12, 24, and 48 h. A degradation rate constant Kdeg was calculated from the concentration time curve of each solution. The length of time required for the gentamicin and tobramycin concentrations to decline to 90% of the initial concentration (t90) was also calculated. The Kdeg of gentamicin in all solutions was less than the Kdeg of tobramycin. The Kdeg increased markedly for gentamicin and tobramycin as the dextrose concentration increased in the PDC. Gentamicin is stable in the 30 and 50% PDC for at least 24 h at 23 °C. Tobramycin, however, demonstrated more than a 10% loss of activity in some PDC solutions. If tobramycin is to be added to PDC, especially the 50% dextrose solution, it should be used within 12 h after admixture.

© 1984 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 03, 1983
Accepted: May 26, 1983
Published online: October 22, 2008
Issue release date: 1984

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: https://www.karger.com/AJN


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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