American Journal of Nephrology

Original Paper

Protein Binding of Disopyramide and Elevated Alpha-1-Acid Glycoprotein Concentrations in Serum Obtained from Dialysis Patients and Renal Transplant Recipients

Haughey D.B. · Kraft C.J. · Matzke G.R. · Keane W.F. · Halstenson C.E.

Author affiliations

Drug Evaluation Unit, Regional Kidney Disease Program, Hennepin County Medical Center, Minneapolis; Schools of Pharmacy and Medicine, University of Minnesota, Minneapolis, Minn., USA

Related Articles for ""

Am J Nephrol 1985;5:35–39

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 03, 1983
Accepted: November 14, 1983
Published online: October 24, 2008
Issue release date: 1985

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: https://www.karger.com/AJN

Abstract

A rapid ultrafiltration technique was used to measure the free (unbound) fraction of disopyramide in serum obtained from 14 normal volunteers, 6 chronic hemodialysis patients, and 10 renal transplant recipients. The disopyramide-free fraction varied more than tenfold at a corresponding total (free plus bound) serum disopyramide concentration of 3 μg/ml and was related to the concentration of an acute-phase protein, alpha-1 -acid glycoprotein (AAG), in patient serum. Moreover, disopyramide-free fraction values were nearly twofold lower than normal in serum specimens obtained from those renal patients and transplant recipients with corresponding AAG serum concentrations greater than 100 mg/l00 ml. AAG concentrations varied tenfold in patient serum and were on average nearly three times higher than AAG concentrations in normal volunteer serum. These findings suggested that the free fraction of disopyramide and possibly other drugs which bind extensively to AAG may be lower, and the interpatient variability in drug binding may be much more pronounced in serum obtained from hemodialysis patients and transplant recipients than previously recognized.

© 1985 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 03, 1983
Accepted: November 14, 1983
Published online: October 24, 2008
Issue release date: 1985

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: https://www.karger.com/AJN


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