American Journal of Nephrology
Original Paper
Abnormally Thin Glomerular Basement Membranes Associated with Hematuria, Proteinuria or Renal Failure in AdultsDische F.E.a · Weston M.J.b · Parsons V.baDepartment of Pathology and bRenal Unit, Dulwich Hospital (King’s College Hospital), London, UK
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Article / Publication Details
Received: September 13, 1983
Accepted: March 02, 1984
Published online: October 24, 2008
Issue release date: 1985
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)
For additional information: https://www.karger.com/AJN
Abstract
Clinical and pathologic findings are described in 14 patients whose main abnormality was an excessively thin glomerular basement membrane (GBM). The subjects were aged 11–51 years, the majority males: most were referred because of hematuria, but proteinuria was the main problem in 2, while hypertension or renal functional impairment was found in several, and 1 was in end-stage renal failure. A history of apparently similar renal symptoms was obtained in another 3 family members. In addition to GBM abnormalities, renal biopsy features included a slight mesangial matrix increase, occasional mesangial cell excess and often appreciable pedicel effacement. There were scanty electron-dense deposits. The mean thickness of the GBM varied from 206 to 301 nm, whereas in IgA nephropathy patients used as controls it was 356-464 nm. It is concluded that some of the lesions in adults are ‘benign’, and some progressive. ‘Thin membrane nephropathy’ is comparatively common among patients seen by the authors, and it is suggested that awareness of this condition will result more often in its recognition.
© 1985 S. Karger AG, Basel
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Article / Publication Details
Received: September 13, 1983
Accepted: March 02, 1984
Published online: October 24, 2008
Issue release date: 1985
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)
For additional information: https://www.karger.com/AJN
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