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Original Research Article

Free Access

Neural Correlates of Caregiver Burden in Cortical Basal Syndrome and Frontotemporal Dementia

Knutson K.M.a · Zamboni G.a, b · Tierney M.C.a · Grafman J.a

Author affiliations

aCognitive Neuroscience Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md., USA; bDipartimento di Neuroscienze, Università di Modena e Reggio Emilia, Modena, Italy

Corresponding Author

Jordan Grafman, PhD, Cognitive Neuroscience Section

National Institutes of Neurological Disorders and Stroke National Institutes of Health, Building 10, Room 7D43, MSC 1440

10 Center Drive, Bethesda, MD 20892-1440 (USA)

Tel. +1 301 496 0220, Fax +1 301 480 2909, E-Mail grafmanj@ninds.nih.gov

Related Articles for ""

Dement Geriatr Cogn Disord 2008;26:467–474

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Abstract

Aims: To determine areas of atrophy in patients that are associated with caregiver burden. Methods: We measured caregiver burden, dementia and neuropsychiatric scores in 22 patients with corticobasal syndrome (CBS) and 25 with frontotemporal dementia (FTD), and in 14 healthy controls. We used voxel-based morphometry to correlate caregiver burden with gray matter loss. Results: Increased dementia and behavioral disturbances contributed to higher burden scores in CBS patients, while behavioral disturbances alone significantly affected burden scores in frontal-variant FTD (FTD-fv) patients. In CBS patients, caregiver burden scores correlated with atrophy in left inferior and middle temporal gyri. Conclusions: Caregivers of FTD-fv patients had significantly higher burden scores than caregivers of CBS patients. Damage to areas important in semantic knowledge appears critical in increased burden for CBS caregivers.

© 2008 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Accepted: August 24, 2008
Published online: November 04, 2008
Issue release date: November 2008

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM


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