American Journal of Nephrology
Laboratory Investigation
Effects of Keto Acid Supplements on Renal Function and Histology in Azotemic Rats Fed High-Protein DietsHirschberg R.a · Cohen A.H.b · Kopple J.D.baSecond Department of Medicine, St. Joseph Hospital, Berlin, FRG; bDepartments of Medicine and Pathology, Harbor-UCLA, Medical Center and UCLA Schools of Medicine and Public Health, Los Angeles, Calif, USA
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Article / Publication Details
Received: March 23, 1987
Accepted: September 10, 1987
Published online: October 24, 2008
Issue release date: 1988
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)
For additional information: https://www.karger.com/AJN
Abstract
The mechanism by which keto-acid-supplemented diets may retard the progression of renal failure is not known. We examined whether the protective effect of keto acids may be independent of a low nitrogen intake. Azotemic sub totally nephrectomized Sprague-Dawley rats were pair-fed a 30% casein diet supplemented with a 10% keto acid mixture (n = 10) or 10% cornstarch (n = 10) for 18 weeks. No differences were observed between the two groups of rats with regard to survival, weight gain, plasma urea, blood pressure, albuminuria, or, at the termination of the study, PAH and inulin clearances. Creatinine clearances, measured weekly during the study, were transiently higher in the keto acid group. There was no difference in the incidence or severity of segmental glomerulosclerosis or tubular atrophy in the two groups. These results indicate that the keto acid mixture used did not exert a protective effect against glomerular sclerosis and progressive albuminuria in azotemic rats fed high-protein diets.
© 1988 S. Karger AG, Basel
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Article / Publication Details
Received: March 23, 1987
Accepted: September 10, 1987
Published online: October 24, 2008
Issue release date: 1988
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)
For additional information: https://www.karger.com/AJN
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