American Journal of Nephrology

Clinical Study

Influence of Therapy with Recombinant Erythropoietin on Serum Levels of Neopterin in Hemodialyzed Subjects

Buemi M.a · Allegra A.b · Aloisi C.a · Frisina N.a

Author affiliations

Chairs of aNephrology II and bMedical Pathology I, Institute of Internal Medicine, Messina University, Messina, Italy

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Am J Nephrol 1991;11:281–283

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: December 10, 1990
Accepted: May 07, 1991
Published online: October 28, 2008
Issue release date: 1991

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: https://www.karger.com/AJN

Abstract

The authors wished to investigate some aspects of the cell-mediated immunity in hemodialyzed subjects undergoing a treatment with recombinant erythropoietin (rHuEPO). The study was carried out through the dosage of the serum levels of neopterin, a substance produced by the macrophages and usable as a marker of their state of activation. The results show a significant reduction of the serum levels of pteridine already at the second month of treatment with rHuEPO (61 ± 9 vs. 95 ± 12 nmol/l), thus proving a probable inhibitory action carried out by erythropoietin on certain cells of the immune system.

© 1991 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: December 10, 1990
Accepted: May 07, 1991
Published online: October 28, 2008
Issue release date: 1991

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: https://www.karger.com/AJN


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