American Journal of Nephrology
Clinical Study
Urinary Acidification Response to Furosemide Administration in Patients on Low-Dose Cyclosporine TherapyQuereda C.a · Soria C.b · Gallego N.a · Sabater J.a · Pascual J.a · Orofino L.a · Ortuno J.aaNephrology and bDermatology Departments, Hospital ‘Ramon y Cajal’, Madrid, Spain
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Article / Publication Details
Received: August 27, 1992
Accepted: January 15, 1993
Published online: October 28, 2008
Issue release date: 1993
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)
For additional information: https://www.karger.com/AJN
Abstract
The response of urinary acidification parameters and electrolytes to furosemide administration was prospectively studied in 9 psoriatic patients treated with a low-dose cyclosporine A schedule (initial dose: 5 mg/kg body weight) before beginning cyclosporine A, after 3 months on cyclosporine A and 1 month after cyclosporine A withdrawal. The test was also performed in 29 psoriatic patients after 3 months on 5 mg/kg body weight cyclosporine A treatment. There were no significant differences between before and after cyclosporine A treatment regarding furosemide-induced changes in urinary volume, sodium or potassium excretion. Contrarily, the post-furosemide urinary pH decrease and ammonium and titrable acid increase were significantly lower in cyclosporine-A-treated patients. Five of the 29 studied patients showed abnormal furosemide tests (17%). These patients had lower total serum CO2, urea and creatinine but similar serum potassium and fractional potassium excretion. We conclude that some patients treated with low-dose cyclosporine A therapy develop an abnormal tubular distal response to furosemide administration, suggesting an alteration in the H+-ATPase pump or a voltage-dependent mechanism.
© 1993 S. Karger AG, Basel
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Article / Publication Details
Received: August 27, 1992
Accepted: January 15, 1993
Published online: October 28, 2008
Issue release date: 1993
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)
For additional information: https://www.karger.com/AJN
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