American Journal of Nephrology
Case Report
Different Effects between Antihypertensive Drugs on Nephrotic-Range Proteinuria in Renovascular HypertensionIshimitsu T. · Yagi H. · Ohkubo M. · Nakamura Y. · Yagi S.Department of Medicine, Division of Hypertension and Cardiorenal Disease, Dokkyo University School of Medicine, Tochigi, Japan
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Article / Publication Details
Received: July 12, 1993
Accepted: November 08, 1993
Published online: October 28, 2008
Issue release date: 1994
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)
For additional information: https://www.karger.com/AJN
Abstract
A 61-year-old man developed renovascular hypertension characterized by nephrotic-range proteinuria. When he was treated with a calcium channel blocker, glomerular filtration fraction was 0.26 and massive proteinuria ranging from 10 to 15 g/day persisted. An angiotensin-converting enzyme inhibitor markedly reduced the proteinuria to 1-2 g/day with a filtration fraction of 0.20. After the antihypertensive drug was switched to a β-blocker, the filtration fraction was 0.23 and urinary protein excretion was 3-4 g/day. Blood pressure control was comparable by each drug. These findings suggest a role of intraglomerular hydraulic mechanism in the etiology of massive proteinuria in renovascular hypertension.
© 1994 S. Karger AG, Basel
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Article / Publication Details
Received: July 12, 1993
Accepted: November 08, 1993
Published online: October 28, 2008
Issue release date: 1994
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)
For additional information: https://www.karger.com/AJN
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