American Journal of Nephrology
Case Report
Diabetes Insipidus as an Early Sign of Pineal TumorTarng D.-C. · Huang T.-P.Division of Nephrology, Department of Medicine, Veterans General Hospital, and National Yang-Ming Medical College, Taipei, Taiwan, ROC
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Article / Publication Details
Received: March 28, 1994
Accepted: July 14, 1994
Published online: October 28, 2008
Issue release date: 1995
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)
For additional information: https://www.karger.com/AJN
Abstract
A 13-year-old boy’s acute onset of diabetes insipidus was the first manifestation of a pineal tumor. One year after the physical symptoms of diabetes insipidus occurred, neurological examinations, tumor markers, and computed tomography brain scan were all normal. Three years later, rapid development of neurological changes was observed with the prevailing symptoms of increased intracranial pressure. The changes were related to a pineal germ cell tumor identified by a high level of β-human chorionic gonadotropin in plasma and neuroradiological investigations, including computed tomography and magnetic resonance imaging. The clinical course of this case is unusual and we advocate the following: (1) the follow-up of children with diabetes insipidus is important for determining whether or not it is an idiopathic type and (2) elevation of plasma β-human chorionic gonadotropin and development of neurological signs in patients with so-called idiopathic diabetes insipidus should arouse clinical suspicion of an intracranial germ cell tumor. It should be noted that the brain tumor is significant as the underlying pathology of childhood diabetes insipidus.
© 1995 S. Karger AG, Basel
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Article / Publication Details
Received: March 28, 1994
Accepted: July 14, 1994
Published online: October 28, 2008
Issue release date: 1995
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)
For additional information: https://www.karger.com/AJN
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