Circadian Relationships between Circulating Atrial Natriuretic Peptides and Serum Sodium and Chloride in Healthy HumansSothern R.B.a · Vesely D.L.b · Kanabrocki E.L.c · Bremner F.W.f · Third J.L.H.C.f · McCormick J.B.g · Dawson S.g · Ryan M.d · Greco J.c · Bean J.T.c · Nemchausky B.M.e · Shirazi P.c · Scheving L.E.h
aRhythmometry Laboratory, St. Paul-Ramsey Medical Center and University of Minnesota, Minneapolis, Minn., bDepartment of Internal Medicine, University of South Florida Health Sciences Center and James A. Haley Veterans Administration Hospital, Tampa, Fla., cNuclear Medicine Service, dNursing Service, and eSpinal Cord Injury, Edward J. Hines, Jr. Veterans Affairs Hospital, Hines, Ill., fCardiovascular Institute, Loyola University Medical Center, Chicago, Ill., gPathology Medicine, Swedish Covenant Hospital, Chicago, Ill., hUniversity of Arkansas for Medical Sciences and John L. McClellan Memorial Veterans Administration Hospital, Little Rock, Ark., USA
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Article / Publication Details
Long-acting natriuretic peptide (LANP), vessel dilator (VSDL), and atrial natriuretic factor (ANF) consisting of amino acids 1-30, 31-67, and 99-126 of the 126 amino acid ANF prohormone, respectively, circulate in humans and have potent natriuretic properties. To determine whether these peptides have a direct relationship to serum Na and/or Cl, we examined 21 24-hour profiles of these peptides and Na and Cl in 14 healthy humans. LANP, VSDL, ANF, and Cl had significant (p < 0.001) circadian rhythms with peak concentrations at 04.00 h. The circadian rhythm of serum Na was exactly opposite. Sodium correlated negatively with LANP (p = 0.021) and ANF (p = 0.007), while Cl correlated positively with LANP (p = 0.003) and VSDL (p = 0.001). These data suggest that the atrial peptides may be important for the maintenance of serum Na and Cl within their normal ranges and in the modulation of their daily circadian rhythms.
© 1996 S. Karger AG, Basel
Article / Publication Details
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