American Journal of Nephrology

Clinical Study

Is the Red Cell Morphology Really Useful to Detect the Source of Hematuria?

Favaro S.a · Bonfante L.a · D’Angelo A.a · Giacomini A.a · Normanno M.a · Caló L.a · Bordin V.a · Vianello D.b · Meani A.b · Antonello A.a · Borsatti A.a

Author affiliations

aInstitute of Internal Medicine, Division of Nepnrology, and b1st Department of Medical Pathology, University of Padua, Italy

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Am J Nephrol 1997;17:172–175

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: September 12, 1995
Accepted: March 13, 1996
Published online: October 28, 2008
Issue release date: 1997

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: https://www.karger.com/AJN

Abstract

Morphological analysis of urinary red blood cells by phase-contrast microscopy to identify the source of bleeding was, and still is, widely used also as a starting point for workup. To evaluate the reliability of this approach, we studied 129 outpatients presenting with persistent isolated microhematuria; 31 subjects also had mild proteinuria (1 g/day), while 21 had pathological albumin levels. All patients were followed for a period of 6 years. During this time, 6 patients underwent renal biopsy for the onset of macrohematuria episodes and proteinuria of 2-3 g/day. Glomerular bleeding was identified in only 14.7% of the patients, despite the persistent microhematuria and the presence of proteinuria or microalbuminuria. The renal origin of the urinary erythrocytes correlated with histological findings in only 2 of 6 patients with dysmorphic erythrocytes who developed proteinuria (exceeding 1 g/day), and none with isomorphic erythrocytes showed urological abnormalities. These results challenge the validity and reliability of morphological analysis to identify the source of bleeding along the urinary tract.

© 1997 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: September 12, 1995
Accepted: March 13, 1996
Published online: October 28, 2008
Issue release date: 1997

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: https://www.karger.com/AJN


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