Blood Purification
Original Paper
Further Investigations of the Defective Protein C in Hemodialysis, Hemofiltration and Continuous Ambulatory Peritoneal DialysisSørensen P.J.a · Nielsen A.H.a · Knudsen F.a · Dyerberg J.bDepartments of aMedicine and Nephrology and bClinical Chemistry (Coagulation Laboratory), Aalborg Hospital, Aalborg, Denmark
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Article / Publication Details
Accepted: December 05, 1988
Published online: October 29, 2008
Issue release date: 1989
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)
For additional information: https://www.karger.com/BPU
Abstract
Protein C activity was determined in patients with terminal renal failure treated in three different ways: hemodialysis (n = 20), hemofiltration (n = 7) and continuous ambulatory peritoneal dialysis (n = 7). The protein C activity was decreased in terminal uremia, independent of the kidney replacement therapy employed, compared with 21 normal controls. In the hemodialysis patients protein C activity increased significantly during a hemodialysis treatment, whereas hemofiltration treatment normalized the depressed protein C activity. In vitro experiments with dialysis and with inhibition of normal plasma with ultrafiltrates could not reveal the presence of an inhibitor of protein C in uremic plasma.
© 1989 S. Karger AG, Basel
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Article / Publication Details
Accepted: December 05, 1988
Published online: October 29, 2008
Issue release date: 1989
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)
For additional information: https://www.karger.com/BPU
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