Kidney and Blood Pressure Research
Original Paper
Function of the Isolated Spontaneously Hypertensive Rat Kidney after Blood Pressure ReductionSteele T.H. · Gottstein J.H. · Challoner-Hue L.Department of Medicine, University of Wisconsin-Madison, Madison, Wisc. USA
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Article / Publication Details
Accepted: September 13, 1984
Published online: November 07, 2008
Issue release date: 1985
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)
For additional information: https://www.karger.com/KBR
Abstract
We treated 20-week-old spontaneously hypertensive rats (SHR) with either placebo or hydralazine, reserpine and hydrochlorothiazide for 1 month. Mean arterial pressure in treated SHR averaged 113 ± 7 mm Hg (mean ± SE), compared to 162 ± 12 mm Hg in animals receiving placebo (p < 0.01). Glomerular filtration rate (GFR) and sodium excretion were similar in both groups. In isolated perfused kidneys, the GFR and sodium excretion were significantly greater in the treatment group than in the placebo group at a perfusion pressure of 140 mm Hg (p < 0.01). Renal vascular resistance (RVR) of kidney from treated SHR was no different from RVR of kidney from placebo SHR. Hydralazine (6 mM) and diazoxide (4 mM) increased the GFR and sodium excretion of isolated SHR kidney perfused at 140 mm Hg (p < 0.05), but decreased RVR significantly (p < 0.05). We conclude that prolonged antihypertensive treatment renders higher GFR values to isolated SHR kidneys perfused at 140 mm Hg, with sodium excretion varying in proportion to the GFR. The addition of vasodilators to the perfusate of isolated SHR kidneys partially reproduced these changes, but only at extremely high concentrations unlike to be attained in vivo.
© 1985 S. Karger AG, Basel
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Article / Publication Details
Accepted: September 13, 1984
Published online: November 07, 2008
Issue release date: 1985
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 1420-4096 (Print)
eISSN: 1423-0143 (Online)
For additional information: https://www.karger.com/KBR
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