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Astrocyte-Neuron Metabolic Pathways

Studies of the Source of Glucose in the Extracellular Compartment of the Rat Brain

Fillenz M. · Lowry J.P.

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University Laboratory of Physiology, University of Oxford, Oxford, UK

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Dev Neurosci 1998;20:365–368

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Article / Publication Details

First-Page Preview
Abstract of Astrocyte-Neuron Metabolic Pathways

Published online: October 30, 1998
Issue release date: July – October 1998

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: https://www.karger.com/DNE

Abstract

Rats were implanted in the striatum with a glucose biosensor glued to a dialysis probe. Changes in extracellular glucose concentration in response to either neuronal stimulation or 3-min periods of hypoxia and hyperoxia were compared when the dialysis probe was perfused with either artificial cerebrospinal fluid (aCSF) alone or aCSF with the addition of the β-adrenoceptor antagonist propranolol. Propranolol had no effect on basal levels of glucose or the changes in glucose produced by hypoxia and hyperoxia, which are attributed to changes in the utilization of glucose. Following neuronal activation there is an initial reduction followed by a delayed, prolonged increase in glucose which is suppressed by propranolol. The results suggest that propranolol has no effect on glucose utilization, but blocks the delivery of glucose from astrocytes.


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Article / Publication Details

First-Page Preview
Abstract of Astrocyte-Neuron Metabolic Pathways

Published online: October 30, 1998
Issue release date: July – October 1998

Number of Print Pages: 4
Number of Figures: 2
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: https://www.karger.com/DNE


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