Cardiology
Cardiovascular Drug Therapy – Current Concepts
Value and Limitations of Thrombolytic Therapy in Early Acute Transmural Myocardial InfarctionDeWood M.A. · Amsterdam E.A.Division of Cardiology, Sacred Heart Medical Center and Deaconess Medical Center, Spokane, Wash.; Division of Cardiovascular Medicine, Department of Internal Medicine, University of California at Davis Medical Center, Sacramento, Calif., USA
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Article / Publication Details
Published online: November 11, 2008
Issue release date: 1985
Number of Print Pages: 55
Number of Figures: 0
Number of Tables: 0
ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)
For additional information: https://www.karger.com/CRD
Abstract
Since coronary thrombosis is the final common pathway by which acute transmural myocardial infarction occurs, intracoronary thrombolytic reperfusion has taken on new significance. The goals of early restoration of coronary blood flow are to reduce mortality as well as to demonstrate improvement of markers of success or failure associated with thrombolytic therapy relative to nonreperfused patients. This paper examines clinical studies from multiple centers and the results derived from these studies. Mortality, left ventricular function, electrocardiographic indices of necrosis, laboratory studies, enzymatic indices of myocardial infarction size, thallium perfusion, and scintigraphic studies from controlled randomized and nonrandomized studies are presented. Overall, it appears that thrombolytic reperfusion is beneficial if applied early, although the markers of success or failure do not necessarily correlate with short-term mortality.
© 1985 S. Karger AG, Basel
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Article / Publication Details
Published online: November 11, 2008
Issue release date: 1985
Number of Print Pages: 55
Number of Figures: 0
Number of Tables: 0
ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)
For additional information: https://www.karger.com/CRD
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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