Cardiology
Original Paper
Hemodynamic and Oxygen Delivery Responses to Nifedipine in Pulmonary Hypertension Secondary to Chronic Obstructive Lung DiseaseSaadjian A.a · Philip-Joet F.b · Arnaud A.baInserm, Unité 278, Unité de recherche et de valorisation en pharmococinétique et toxicocinétique, Faculté de Pharmacie; Service de Cardiologie CHU-Nord, Université d’Aix-Marseille II, et bService de Pneumologie et d’Allergie respiratoire, CHU-Nord, Université d’Aix-Marseille II, Marseille, France
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Article / Publication Details
Received: April 17, 1986
Accepted: July 27, 1986
Published online: November 11, 2008
Issue release date: 1987
Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0
ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)
For additional information: https://www.karger.com/CRD
Abstract
The effects of a single dose of nifedipine (20 mg sublingually) on hemodynamics and tissue oxygenation were evaluated in 24 patients suffering from pulmonary hypertension secondary to severe chronic obstructive lung disease. A significant improvement in pulmonary circulation and right ventricular pump function occurred. An increase in the oxygen delivery to the tissue was also demonstrated. A complementary study in 10 patients showed that the effects observed after a single dose were still apparent after oral intake (30 mg/day) for 15 days. For these reasons nifedipine may contribute in the treatment of cor pulmonale.
© 1987 S. Karger AG, Basel
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Article / Publication Details
Received: April 17, 1986
Accepted: July 27, 1986
Published online: November 11, 2008
Issue release date: 1987
Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0
ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)
For additional information: https://www.karger.com/CRD
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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