Upregulation of Chemokine and Cytokine Production during PregnancySegerer S. · Kämmerer U. · Kapp M. · Dietl J. · Rieger L.
Department of Obstetrics and Gynecology, University of Würzburg, Würzburg, Germany
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Article / Publication Details
Background: Following implantation, endometrial stroma is transformed into decidual tissue via a complex remodeling process. In parallel with that process, a significant increase in immune cells can be detected. Several studies suggest that chemokines and cytokines orchestrate the transformation of decidual tissue and the infiltration of leukocytes. In this study, we therefore compared chemokine and cytokine expression in the first- and third-trimester nonpregnant endometrium and decidua. Methods: Investigation of the expression patterns of cytokines, chemokines and growth factors in endometrial tissue (after routine hysterectomy) and human decidual tissue (7–8 weeks of gestation and 38–40 weeks of gestation, respectively) was performed by protein array analysis. Results: This analysis revealed a significant increase in monocyte-attracting chemokines (granulocyte-macrophage colony-stimulating factor, growth-related oncogene, growth-related oncogene-α and monocyte chemoattractant protein-2) , granulocyte-attracting chemokines (epithelial neutrophil activating peptide and interleukin 8) and proinflammatory factors (interleukin-1α, leptin) in decidual compared to endometrial tissue. Furthermore, concentrations of angiogenic substances (vascular endothelial growth factor and thrombopoietin) significantly peaked in first-trimester deciduas. Conclusion: This study demonstrates increased expression of chemokines and cytokines in decidual tissue compared to nonpregnant endometrium.
© 2008 S. Karger AG, Basel
- Bulmer JN, Morrison L, Longfellow M, Ritson A, Pace D: Granulated lymphocytes in human endometrium: histochemical and immunohistochemical studies. Hum Reprod 1991;6:791–798.
- Kammerer U, Eggert AO, Kapp M, et al: Unique appearance of proliferating antigen-presenting cells expressing DC-SIGN (CD209) in the decidua of early human pregnancy. Am J Pathol 2003;162:887–896.
- Jones RL, Hannan NJ, Kaitu’u TJ, Zhang J, Salamonsen LA: Identification of chemokines important for leukocyte recruitment to the human endometrium at the times of embryo implantation and menstruation. J Clin Endocrinol Metab 2004;89:6155–6167.
- Engert S, Rieger L, Kapp M, Becker JC, Dietl J, Kammerer U: Profiling chemokines, cytokines and growth factors in human early pregnancy decidua by protein array. Am J Reprod Immunol 2007;58:129–137.
- Bischof P, Meisser A, Campana A: Mechanisms of endometrial control of trophoblast invasion. J Reprod Fertil Suppl 2000;55:65–71.
- Lea RG, Sandra O: Immunoendocrine aspects of endometrial function and implantation. Reproduction 2007;134:389–404.
- Sharkey AM, Smith SK: The endometrium as a cause of implantation failure. Best Pract Res Clin Obstet Gynaecol 2003;17:289–307.
- Kelly RW, King AE, Critchley HO: Cytokine control in human endometrium. Reproduction 2001;121:3–19.
- Osman I, Young A, Ledingham MA, Thomson AJ, Jordan F, Greer IA, Norman JE: Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term. Mol Hum Reprod 2003;9:41–45.
- Osman I, Young A, Jordan F, Greer IA, Norman JE: Leukocyte density and proinflammatory mediator expression in regional human fetal membranes and decidua before and during labor at term. J Soc Gynecol Investig 2006;13:97–103.
- Kniss DA, Zimmerman PD, Fertel RH, Iams JD: Proinflammatory cytokines interact synergistically with epidermal growth factor to stimulate PGE2 production in amnion- derived cells. Prostaglandins 1992;44:237–244.
- Brown NL, Alvi SA, Elder MG, Bennett PR, Sullivan MH: Interleukin-1beta and bacterial endotoxin change the metabolism of prostaglandins E2 and F2alpha in intact term fetal membranes. Placenta 1998;19:625–630.
- Calder AA, Greer IA: Pharmacological modulation of cervical compliance in the first and second trimesters of pregnancy. Semin Perinatol 1991;15:162–172.
- Fuchs AR, Fuchs F: Endocrinology of human parturition: a review. Br J Obstet Gynecol 1984;91:948–967.
- Huppertz B, Peeters LL: Vascular biology in implantation and placentation. Angiogenesis 2005;8:157–167.
- Sharkey AM, Charnock-Jones DS, Boocock CA, Brown KD, Smith SK: Expression of mRNA for vascular endothelial growth factor in human placenta. J Reprod Fertil 1993;99:609–615.
- Clark DE, Smith SK, Sharkey AM, Charnock-Jones DS: Localization of VEGF and expression of its receptors flt and KDR in human placenta throughout pregnancy. Hum Reprod 1996;11:1090–1098.
- Koch AE, Polverini PJ, Kunkel SL, et al: Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 1992;258:1798–1801.
- Kirito K, Fox N, Komatsu N, Kaushansky K: Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-1alpha. Blood 2005;105:4258–4263.
- Charnock-Jones DS, Sharkey AM, Rajput-Williams J, et al: Identification and localization of alternately spliced mRNAs for vascular endothelial growth factor in human uterus and estrogen regulation in endometrial carcinoma cell lines. Biol Reprod 1993;48:1120–1128.
- Sharkey AM, Day K, McPherson A, et al: Vascular endothelial growth factor expression in human endometrium is regulated by hypoxia. J Clin Endocrinol Metab 2000;85:402–409.
- Li XF, Gregory J, Ahmed A: Immunolocalisation of vascular endothelial growth factor in human endometrium. Growth Factors 1994;11:277–282.
- Trundley A, Moffett A: Human uterine leukocytes and pregnancy. Tissue Antigens 2004;63:1–12.
- Savion S, Zeldich E, Orenstein H, Shepshelovich J, Torchinsky A, Carp H, Toder V, Fein A: Cytokine expression in the uterus of mice with pregnancy loss: effect of maternal immunopotentiation with GM-CSF. Reproduction 2002;123:399–409.
- Wegmann TG, Athanassakis I, Guilbert IJ, Menu E, Chaouat G: The role of M-CSF and GM-CSF in fostering placental growth and fetal survival. Transplant Proc 1989;21:566–568.
- Rieger L, Honig A, Sutterlin M, et al: Antigen-presenting cells in human endometrium during the menstrual cycle compared to early pregnancy. J Soc Gynecol Investig 2004;11:488–493.
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