Cardiology

HMG CoA Reductase Inhibitors: New Horizons in the Management of Hypercholesterolemia

Effect of Cholesterol-Lowering Treatment on Coronary Heart Disease Morbidity and Mortality: The Evidence from Trials, and Beyond

Katan M.B.

Author affiliations

Department of Human Nutrition, Wageningen Agricultural University, Wageningen, The Netherlands

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Cardiology 1990;77:8–13

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Article / Publication Details

First-Page Preview
Abstract of HMG CoA Reductase Inhibitors: New Horizons in the Management of Hypercholesterolemia

Published online: November 12, 2008
Issue release date: 1990

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: https://www.karger.com/CRD

Abstract

Evidence from controlled clinical trials shows convincingly that reducing serum cholesterol levels by diet or drug treatment reduces the incidence of coronary heart disease. On a population basis, the most important effect of cholesterol lowering might be postponement of the first symptoms of disease rather than postponement of death, because most cardiac deaths occur at an advanced age. No enhanced cancer mortality is seen either in populations with low serum cholesterol levels or in patients who, through a genetic defect, have a low-density-lipoprotein cholesterol of zero. This makes it unlikely that cholesterol-lowering treatment as such promotes cancer. Still, specific side effects and toxicity of drugs need careful scrutiny, and diet remains the treatment of choice for mild hypercholesterolemia.

© 1990 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of HMG CoA Reductase Inhibitors: New Horizons in the Management of Hypercholesterolemia

Published online: November 12, 2008
Issue release date: 1990

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: https://www.karger.com/CRD


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