Cardiology
General Cardiology
Assessment of Left Ventricular Dysfunction in Acromegalic Patients Using Radionuclide Ventriculography ParametersErbas T.a · Erbas B.b · Usman A.a · Bekdik C.F.bHacettepe University, Faculty of Medicine, Departments of aEndocrinology and bNuclear Medicine, Sihhiye-Ankara, Turkey
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Article / Publication Details
Received: December 17, 1991
Accepted: December 19, 1991
Published online: November 12, 2008
Issue release date: 1992
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)
For additional information: https://www.karger.com/CRD
Abstract
The left ventricular function of 14 acromegalic patients was investigated using radionuclide ventriculography. After labeling the red blood cells with 750-1,000 MBq 99mTc-pertechnetate, ECG-triggered left anterior oblique images were recorded. Fourier analysis was then performed on the time-activity curve of the left ventricle. The ejection fraction (EF), peak ejection rate, time to peak ejection (TPE), time to endsystole (TES), peak filling rate (PFR), time to peak filling (TPF), 1/3 EF, 1/3 filling fraction (FF), TPE/T, TPF/T and TES/T values (T: time interval for one heart beat) were calculated for each patient. Five patients (35.7%) had clinical cardiovascular symptoms. A decreased EF was observed in 28.5% of the patients. In comparison to the control group, the EF (53.5 ± 5.5 vs. 60.8 ± 5%p < 0.009), 1/3 EF(14.45 ± 3vs.20 ± 4%, p < 0.001), 1/3 FF (28.5 ± 10.6 vs. 41 ± 11%, p < 0.02), TPE (158 ± 33 vs. 132 ± 35 msp < 0.01), TPE/T (20.2 ± 5 vs. 16 ± 3.7, p < 0.01) and PFR (2.4 ± 0.5 vs. 2.9 ± 0.4 EDC/s, p < 0.005) were significantly different. It was found that TPE was prolonged and the early ejection function was decreased. Diastolic dysfunction was found in 5 (35.7%) patients; 21.4% of the patients had decreased PFR values although they had no cardiac symptom, hypertension and/or cardiomegaly. Scintigraphic parameters did not correlate with the presence of hypertension, cardiomegaly or cardiovascular symptoms. In summary, using radionuclide ventriculography parameters, systolic and diastolic dysfunction were observed in 28.5 and 35.7% of acromegalic patients, respectively.
© 1992 S. Karger AG, Basel
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Article / Publication Details
Received: December 17, 1991
Accepted: December 19, 1991
Published online: November 12, 2008
Issue release date: 1992
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)
For additional information: https://www.karger.com/CRD
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