Annals of Nutrition and Metabolism

Original Paper

Effect of Repletion with Dietary Calcium on Composition and Mechanical Properties of Bone of Calcium-Deprived Rats

Galfsky I. · Wolinsky I. · Simkin A. · Guggenheim K.

Author affiliations

Hebrew University-Hadassah School of Dental Medicine, Department of Nutrition, Hebrew University-Hadassah Medical School, Department of Orthopedic Surgery, Hadassah University Hospital, Jerusalem, and School of Nutritional and Domestic Sciences, Faculty of Agriculture, Hebrew University, Rehovoth

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Nutr Metab 1975;18:99–104

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 17, 1974
Accepted: February 14, 1975
Published online: November 13, 2008
Issue release date: 1975

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: https://www.karger.com/ANM

Abstract

Four groups of rats were fed a low-calcium diet (0.02 %) and two groups a normal calcium diet (0.50 %). After 2 weeks one group from each dietary calcium level was sacrificed and the femurs examined. The remaining three groups which had been kept on the low-calcium diet were then given diets richer in calcium: 0.25, 0.35 and 0.5 %. The remaining group on the normal calcium diet continued receiving it. After two more weeks all animals were sacrificed and their femurs examined. Rats fed the low-calcium diet lagged behind in weight gain; ash content, breaking strength, and modulus of elasticity of their femurs were much lower than those of animals on the normal calcium diet. Feeding diets with increasing calcium content increased bone ash and improved mechanical properties. However, improvement of breaking strength and elasticity did not parallel strictly increases in mineralization. Repletion with a normal calcium diet (0.50 %) failed to increase bone ash to normal levels but mechanical properties were improved by repletion with substantially lower dietary calcium levels. Maximal breaking strength was obtained by repletion feeding with a dietary calcium level which failed to increase bone ash. It seems that factors other than mineralization determine breaking strength and elasticity of bone recovering from calcium deprivation.

© 1975 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 17, 1974
Accepted: February 14, 1975
Published online: November 13, 2008
Issue release date: 1975

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: https://www.karger.com/ANM


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