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Advances in the Management of Testosterone Deficiency

Editor(s): Jones T.H. (Barnsley/Sheffield) 
Cover

Testosterone, Bone and Osteoporosis

Tuck S. · Francis R.

Author affiliations

aDepartment of Rheumatology, James Cook University Hospital, Middlesbrough, and bSchool of Clinical Medical Sciences, University of Newcastle upon Tyne, Medical School, Newcastle upon Tyne, UK

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Jones, T.H. (Barnsley/Sheffield) (eds): Advances in the Management of Testosterone Deficiency. Front Horm Res. Basel, Karger, 2009, vol 37, pp 123-132

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: November 17, 2008
Cover Date: 2009

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8622-1 (Print)
eISBN: 978-3-8055-8623-8 (Online)

Abstract

Osteoporosis and osteoporotic fractures are generally considered to mainly affect older postmenopausal women, but up to 20% of symptomatic vertebral fractures and 30% of hip fractures occur in men. Osteoporotic fractures in men are associated with substantial morbidity, greater excess mortality than in women and account for almost 25% of the cost of osteoporotic fractures in the UK. One of the major secondary causes of osteoporosis in men is hypogonadism, which is found in up to 20% of men with symptomatic vertebral fractures and 50% of elderly men with hip fractures. This chapter outlines the pathogenesis of osteoporosis in men, placing particular emphasis on the importance of sex steroids in the maintenance of bone health. The effects of hypogonadism on the skeleton are described, as well as the consequences of androgen deprivation therapy in men with prostate cancer. Finally, we review the effects of testosterone replacement in hypogonadism and explore other options for the treatment of osteoporosis secondary to loss of sex steroids in men.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: November 17, 2008
Cover Date: 2009

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8622-1 (Print)
eISBN: 978-3-8055-8623-8 (Online)


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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