Cardiology
General Cardiology
Detection of Circulating Alpha-Actinin in Non-Insulin-Dependent Diabetics with Autonomic DysfunctionPrados J.a · Melguizo C.a · Aránega A.E.b · Escobar-Jimenez F.c · Cobo V.C.c · Aránega° A.caDepartment of Health Sciences and Clinical Psychology, University of Almería, bBasic Cardiovascular Research Section, Department of Morphological Sciences, University of Granada School of Medicine, Granada, and cEndocrinology Service, University of Granada Hospital, Granada, Spain
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Article / Publication Details
Received: April 24, 1995
Accepted: July 28, 1995
Published online: November 19, 2008
Issue release date: 1996
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)
For additional information: https://www.karger.com/CRD
Abstract
The presence of cardiac proteins in serum has been related to ischemic heart diseases such as acute myocardial infarction and angina pectoris, which are more frequent in non-insulin-dependent diabetic patients. Silent myocardial ischemia, which is also more frequent in these patients, occurs in association with autonomic dysfunction. We used Western blot analysis to search the myocardial protein α-actinin in sera from non-insulin-dependent diabetic patients with or without autonomic dysfunction. Of the 24 diabetic patients with neuropathy, 18 were positive for circulating α-actinin; this protein was found in only 1 of the 22 diabetic patients without neuropathy. Our results showed a significant correlation between non-insulin-dependent diabetic patients with neuropathy and detectable circulating α-actinin in serum, and suggest that the determination by immunoblotting of serum α-actinin in these patients may be an effective method to detect myocardial cell impairment, and to identify diabetic patients that may need special consideration.
© 1996 S. Karger AG, Basel
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Article / Publication Details
Received: April 24, 1995
Accepted: July 28, 1995
Published online: November 19, 2008
Issue release date: 1996
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)
For additional information: https://www.karger.com/CRD
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