Annals of Nutrition and Metabolism
Original Paper
Effect of Varying Levels of Magnesium during Gestation and Lactation on Humoral Immune Response and Tissue Minerals in RatsKubena K.S. · Cohill D.T. · McMurray D.N.Department of Animal Science, Texas A&M University, College Station, Tex., USA
Keywords: MagnesiumMagnesium deficiencyImmunity |
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Article / Publication Details
Received: December 22, 1987
Accepted: September 30, 1988
Published online: November 19, 2008
Issue release date: 1989
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)
For additional information: https://www.karger.com/ANM
Abstract
Weanling rats were maintained on diets which were Mg-adequate (49 mmol Mg/kg), groups 1 and 3, or Mg-deficient (8 mmol Mg/kg), groups 2 and 4, for 8 weeks of growth. During breeding, gestation, and lactation, groups 3 and 4 received diets supplemented with 41 mmol Mg/kg. Femur and cardiac Mg in group 2 dams was reduced, confirming that Mg deficiency was present. Thymic weight from dams and pups and numbers of plaque-forming cells in pups in group 1 were higher than in other groups while splenic weight in pups was lowest in group 2. Results indicate that maternal magnesium deficiency impaired immunocompetence in offspring. Regardless of the presence or absence of pregestational magnesium deficiency, magnesium supplementation also was associated with depressed immune function.
© 1989 S. Karger AG, Basel
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Article / Publication Details
Received: December 22, 1987
Accepted: September 30, 1988
Published online: November 19, 2008
Issue release date: 1989
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)
For additional information: https://www.karger.com/ANM
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