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Vaccines and Diagnostics for Transboundary Animal Diseases

International Symposium, Ames, Iowa, September 2012: Proceedings

Editor(s): Roth J.A. (Ames, Iowa) 
Richt J.A. (Manhattan, Kans.) 
Morozov I.A. (Manhattan, Kans.) 
Cover

Session II: State of the art, progress and gaps in development of vaccines and ...

Review of Ebola Virus Infections in Domestic Animals

Weingartl H.M.1 · Nfon C.1 · Kobinger G.2

Author affiliations

1 National Centre for Foreign Animal Disease (NCFAD), Canadian Food Inspection Agency (CFIA), Canadian Science Centre for Human and Animal Health, Winnipeg, Canada;2 National Microbiology Laboratory (NML), Public Health Agency of Canada (PHAC), Canadian Science Centre for Human and Animal Health, Winnipeg, Canada

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Roth JA, Richt JA, Morozov IA (eds): Vaccines and Diagnostics for Transboundary Animal Diseases. Dev Biol (Basel). Basel, Karger, 2013, vol 135, pp 211-218.

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Article / Publication Details

Published online: May 14, 2013
Cover Date: 2013

ISBN: 978-3-318-02365-7 (Print)
eISBN: 978-3-318-02366-4 (Online)

Abstract

Ebola viruses (EBOV; genus Ebolavirus, family Filoviridae) cause often fatal, hemorrhagic fever in several species of simian primates including human. While fruit bats are considered a natural reservoir, the involvement of other species in the EBOV transmission cycle is unclear, especially for domesticated animals. Dogs and pigs are so far the only domestic animals identified as species that can be infected with EBOV. In 2009 Reston-EBOV was the first EBOV reported to infect swine with indicated transmission to humans; and a survey in Gabon found over 30% seroprevalence for EBOV in dogs during the Ebola outbreak in 2001-2002. While infections in dogs appear to be asymptomatic, pigs experimentally infected with EBOV can develop clinical disease, depending on the virus species and possibly the age of the infected animals. In the experimental settings, pigs can transmit Zaire-Ebola virus to naive pigs and macaques; however, their role during Ebola outbreaks in Africa needs to be clarified. Attempts at virus and antibody detection require as a prerequisite validation of viral RNA and antibody detection methods especially for pigs, as well as the development of a sampling strategy. Significant issues about disease development remain to be resolved for EBOV. Evaluation of current human vaccine candidates or development of veterinary vaccines de novo for EBOV might need to be considered, especially if pigs or dogs are implicated in the transmission of an African species of EBOV to humans.

© 2013 by the International Alliance for Biological Standardization (IABS), Carouge-Geneva (Switzerland)


References

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Article / Publication Details

Published online: May 14, 2013
Cover Date: 2013

ISBN: 978-3-318-02365-7 (Print)
eISBN: 978-3-318-02366-4 (Online)


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.