Login to MyKarger

New to MyKarger? Click here to sign up.



Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Opening Lecture

The Sebaceous Gland and Acne – 40 Years On

Cunliffe W.J.

Author affiliations

Skin Research Centre, University of Leeds, UK

Related Articles for ""

Dermatology 1998;196:9–15

Do you have an account?

Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.


Save over 20% compared to the individual article price.
Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00


Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Opening Lecture

Published online: March 13, 1998
Issue release date: 1998

Number of Print Pages: 7
Number of Figures: 11
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM

Abstract

The purpose of this paper is to provide a review of the aetiology of acne and its treatment but more importantly to stress throughout this review the immense contributions made by Prof. J.S. Strauss in the field of sebaceous gland and acne research.


References

  1. Strauss JS, Pochi PE: The quantative gravimetric determination of sebum production. J Invest Dermatol 1961;36:293–297.
  2. Pochi PE, Strauss JS: Sebum production, casual sebum levels, titratable acidity of sebum and urinary fractional 17-ketosteroid excretion in males with acne. J Invest Dermatol 1964;43: 383–388.
  3. Pochi PE, Strauss JS: Endocrinologic control of the development and activity of the human sebaceous gland. J Invest Dermatol 1974;62: 191–201.
  4. Pochi PE, Strauss JS, Rao CS, et al: Plasma testosterone and estrogen levels, urine testosterone excretion, and sebum production in males with acne vulgaris. J Clin Endocrinol Metab 1965;25:1660–1664.
    External Resources
  5. Ebling FJ: Hormonal control and methods of measuring sebaceous gland activity. J Invest Dermatol 1974;62:161–171.
    External Resources
  6. Imperato-McGinley J, Gautier T, Cai L-Q, Yee B, Epstein J, Pochi P: The androgen control of sebum production: Studies of subjects with dihydrotestosterone deficiency and complete androgen insensitivity. J Clin Endocrinol Metab 1993;76:524–528.
  7. Thiboutot D, Harris G, Iles V, Cimis G, Gilliland K, Hagari S: Activity of the type 1 5-alpha-reductase exhibits regional differences in isolated sebaceous glands and whole skin. J Invest Dermatol 1995;105:209–214.
  8. Lucky AW, Biro FM, Huster GA, Leach AD, Morrison JA, Ratterman J: Acne vulgaris in premenarchal girls: An early sign of puberty associated with rising levels of dehydroepiandrosterone. Arch Dermatol 1994;130: 308–314.
  9. Lucky AW, McClure J, Rosenfield RL, et al: Plasma androgens in women with acne vulgaris. J Invest Dermatol 1983;81:70–74.
    External Resources
  10. Odlind V, Carlstrom K, Michaelsson C, et al: Plasma androgenic activity in women with acne vulgaris and in healthy girls before, during and after puberty. Clin Endocrinol 1982; 16:243–249.
  11. Carmina E, Lobo RA: Evidence for increased andosterone metabolism in some normoandrogenic women with acne. J Clin Endocrinol Metab 1993;76:1111–1114.
  12. Schmidt JB, Spona J, Huber J: Androgen receptor in hirsutism and acne. Gynecol Obstet Invest 1986;22:206–211.
    External Resources
  13. Piérard GE: Follicle to follicle heterogeneity of sebum excretion. Dermatologica 1986;173: 61–65.
  14. Piérard GE, Piérard-Franchimont C, Kligman AM: Kinetics of sebum excretion evaluated by the Sebutape-Chromameter technique. Skin Pharmacol 1993;6:38–44.
  15. Strauss JS, Kligman AM: The pathologic dynamics of acne vulgaris. Br J Dermatol 1960; F5082:779–790.
  16. Holmes RL, Williams M, Cunliffe WJ: Pilosebaceous duct obstruction and acne. Br J Dermatol 1972;87:327–332.
  17. Plewig G, Fulton FE, Kligman AM: Cellular dynamics of comedo formation in acne vulgaris. Arch Dermatol Forsch 1971;242:12–29.
  18. Knaggs HE, Holland DB, Morris C, Wood EJ, Cunliffe WJ: Quantification of cellular proliferation in acne using the monoclonal antibody Ki-67. Soc Invest Dermatol 1994;102:89–92.
  19. Kanaar P: Follicular-keratinogenic properties of fatty acids in the external ear canal of the rabbit. Dermatologica 1971;142:14–22.
  20. Kligman AM, Katz AC: Pathogenesis of acne vulgaris. I. Comedogenesis properties of human sebum in external ear canal of the rabbit. Arch Dermatol 1968;98:53–57.
  21. Wertz PW, Miethke MC, Long SA, et al: The composition of the ceramides from human stratum corneum and from comedones. J Invest Dermatol 1985;84:410–412.
    External Resources
  22. Downing DT, Stewart ME, Wertz PW, et al: Essential fatty acids and acne. J Am Acad Dermatol 1986;14:221–225.
  23. Thiboutot D, Knaggs H, Gilliland K, Hagari S: Activity of type 1 5α-reductase is greater in the follicular infrainfundibulum compared with the epidermis. Br J Dermatol 1997;136: 166–171.
  24. Guy R, Ridden C, Barth J, Kealey T: Isolation and maintenance of the human pilosebaceous duct: 13-cis-Retinoic acid acts directly on the duct in vitro. Br J Dermatol 1993;128: 242–248.
  25. Guy R, Green MR, Kealey T: Modelling acne in vitro. J Invest Dermatol 1996;106:176–182.
  26. Marples RR: The microflora of the face and acne lesions. J Invest Dermatol 1974;62: 326–331.
    External Resources
  27. Holland KT, Cunliffe WJ, Roberts CD: The role of bacteria in acne vulgaris – A new approach. Clin Exp Dermatol 1978;3:253–257.
    External Resources
  28. Gribbon EM, Shoesmith JG, Cunliffe WJ, Holland KT: The microaerophily and photosensitivity of Propionibacterium acnes. J Appl Bacteriol 1994;77:583–590.
    External Resources
  29. Norris JF, Cunliffe WJ: A histological and immunocytochemical study of early acne lesions. Br J Dermatol 1988;118:651–659.
  30. Ingham E, Holland KT, Gowland C, et al: Studies of the extracellular proteolytic activity produced by Propionibacterium acnes. J Appl. Bacteriol 1983;54:263–271.
  31. Puhvel SM, Sakamoto M: An in vitro evaluation of the inflammatory effect of purified comedonal components in human skin. J Invest Dermatol 1977;69:401–406.
    External Resources
  32. Webster GF: Inflammation in acne vulgaris. J Am Acad Dermatol 1995;33(2, pt 1):247–253.
  33. Walters CE, Ingham E, Eady EA, Cove JH, Kearney JN, Cunliffe WJ: In vitro modulation of keratinocyte-derived interleukin-1 alpha (IL-1 alpha) and peripheral blood mononuclear cell-derived IL-1 beta release in response to cutaneous commensal microorganisms. Infect Immun 1995;63:1223–1228.
  34. Strauss JS, Rapini RP, Shalita AR, et al: Isotretinoin therapy for acne: Results of a multicenter dose-response study. J Am Acad Dermatol 1984;10:490–496.
  35. Leyden JJ, McGinley KJ, Foglia AN: Qualitative and quantitative changes in cutaneous bacteria associated with systemic isotretinoin therapy for acne conglobata. J Invest Dermatol 1986;86:390–393.
  36. Pochi PE, Strauss SS: Sebaceous gland suppression with ethinyl estradiol and diethylstilbestrol. Arch Dermatol 1973;108:210–214.
  37. Farrell LN, Strauss JS, Stranieri AM: The treatment of severe cystic acne with 13-cis-retinoic acid: Evaluation of sebum production and the clinical response in a multiple dose trial. J Am Acad Dermatol 1980;3:602–611.
    External Resources
  38. Karvonen S: Acne fulminans: Report of clinical findings and treatment of twenty-four patients. J Am Acad Dermatol 1993;28:572–579.
  39. Plewig G, Jansen T, Kligman A: Pyoderma faciale – A review and report of 20 additional cases: Is it rosacea? Arch Dermatol 1992;128: 1611–1617.
  40. Harms M, Masouyé I, Radeff B: The relapses of cystic acne after isotretinoin treatment are age related: A long-term follow-up study. Dermatologica 1986;172:148–153.
    External Resources
  41. Piagatto PD, Fiorini A, Fiva F, et al: Effects of isotretinoin on the neutrophil chemotaxis in cystic acne. Dermatologica 1983;167:16–18.
    External Resources
  42. Marks VJ, Briggaman RA: Pyoderma faciale: Successful treatment with isotretinoin. J Am Acad Dermatol 1987;17:1062–1063.

Article / Publication Details

First-Page Preview
Abstract of Opening Lecture

Published online: March 13, 1998
Issue release date: 1998

Number of Print Pages: 7
Number of Figures: 11
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.