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Pharmacology and Treatment

Anti-Inflammatory Effect of Hamamelis Lotion in a UVB Erythema Test

Hughes-Formella B.J.a · Bohnsack K.b · Rippke F.b · Benner G.b · Rudolph M.b · Tausch I.a · Gassmueller J.a

Author affiliations

aBioSkin, Institute for Dermatological Research and Development, and bBeiersdorf AG, Hamburg, Germany

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Dermatology 1998;196:316–322

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Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Published online: May 15, 1998
Issue release date: 1998

Number of Print Pages: 7
Number of Figures: 5
Number of Tables: 3

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM

Abstract

Background: Although Hamamelis virginiana has long been used in the traditional treatment of skin diseases, there are few controlled clinical studies defining the extent of its anti-inflammatory action. Objective:The anti-inflammatory efficacy of pH5 Eucerin aftersun lotion with 10% hamamelis distillate, the vehicle and a prior aftersun formulation were tested in 30 healthy volunteers using a modified UVB erythema test as model of inflammation. Methods: Four UVB doses ranging from 1 to 2 MED were evaluated in each subject. Test fields on the back were treated occlusively for 48 h following irradiation. Chromametry and visual scoring were used to determine the degree of erythema in the treated fields and an untreated, irradiated control field 7, 24 and 48 h after irradiation. Results: Erythema suppression ranged from approximately 20% at 7 h to 27% at 48 h in the hamamelis fields. A suppression of 11–15% was recorded in the fields treated with the other lotions. Significant differences were noted between hamamelis and these lotions. Conclusion: These data provide evidence for an anti-inflammatory action of the aftersun lotion with 10% hamamelis and support the usefulness of the UVB erythema test with multiple UV doses for the testing of nonsteroidal anti-inflammatory agents.


References

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  3. Korting HC, Schäfer-Korting M, Hart H, Laux P, Schmid M: Anti-inflammatory activity of hamamelis distillate applied topically to the skin. Eur J Clin Pharmacol 1993;44:315–318.
  4. Swoboda M, Meurer J: Therapie von Neurodermitis mit Hamamelis-virginiana-Extract in Salbenform. Z Phytother 1991;12:114–117.
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    External Resources
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    External Resources
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    External Resources
  10. COLIPA sun protection factor test method, ref. 94/289 – October 1994. Bruxelles, European Cosmetic, Toiletry and Perfumery Association – COLIPA, 1994.
  11. Queille-Roussel C, Duteil L, Czernielewski J, Schaeffer H: Colorimetric evaluation of the human skin blanching assay; in Frosch PJ, Kligman AM (eds): Noninvasive Methods for the Quantification of Skin Functions. Berlin, Springer, 1993, pp 92–103.
  12. Elsner P: Chromametry: Hardware, measuring principles, and standardization of measurements; in Berardesca E, Elsner P, Maibach HI (eds): Bioengineering of the Skin: Cutaneous Blood Flow and Erythema. Boca Raton, CRC Press, 1995, pp 247–252.

Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Published online: May 15, 1998
Issue release date: 1998

Number of Print Pages: 7
Number of Figures: 5
Number of Tables: 3

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM


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