International Journal of Microcirculation

Original Paper

Serotonin – One Possible Link between Oxygen Metabolism and the Regulation of Blood Flow in the Brain?

Gustafsson U.a · Sjöberg F.b

Author affiliations

aClinical Research Center, and bBurns Intensive Care Unit, Department of Hand and Plastic Surgery and Department of Anesthesiology and Intensive Care, Faculty of Health Sciences, University Hospital, Linköping, Sweden

Related Articles for ""

Int J Microcirc 1996;16:143–146

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 12, 1995
Accepted: February 26, 1996
Published online: November 25, 2008
Issue release date: 1996

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0167-6865 (Print)
eISSN: 1573-1057 (Online)

For additional information: https://www.karger.com/IJC

Abstract

Hyperoxemia is known to alter tissue oxygenation, which in the brain results in a scattered and an uneven distribution of cerebrocortical tissue oxygen pressures (PtO2). This study examined the effect of ritanserin (a highly specific serotonin receptor antagonist, 5-HT2) on the PtO2 distribution during hyperoxemia. The measurements of brain oxygenation were performed on the motor cortex in anesthetized pigs with a multiwire Clark-type microelectrode. Ritanserin was administered (0.035 mg/kg i.v.) during hyperoxemia (inspired oxygen fraction = 0.70). In 4 of 5 animals, the disturbed oxygenation that was registered during hyperoxemia was normalized after the ritanserin injection. These results indicate that serotonin may be involved in the regulation of brain oxygenation during hyperoxemia, and they also suggest that serotonin may be a link in the coupling between the oxygen metabolism and the regulation of blood flow in the brain.

© 1996 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 12, 1995
Accepted: February 26, 1996
Published online: November 25, 2008
Issue release date: 1996

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0167-6865 (Print)
eISSN: 1573-1057 (Online)

For additional information: https://www.karger.com/IJC


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