Hormone Research in Paediatrics
Low-Renin, Low-Aldosterone Hypertension and Abnormal Cortisol Metabolism in a 19-Month-Old ChildFiselier T.J.W.a · Otten B.J.a · Monnens L.A.H.a · Honour J.W.b · van Munster P.J.J.aaDepartment of Paediatrics, University of Nijmegen, The Netherlands; bClinical Research Centre, Harrow, Middlesex, England
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Article / Publication Details
Published online: November 25, 2008
Issue release date: 1982
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: https://www.karger.com/HRP
Abstract
A 19-month-old boy presented with failure to thrive and polydipsia. Low-renin hypertension was diagnosed by the presence of hypertension, hypokalaemic alkalosis, suppressed plasma renin activity and low plasma aldosterone. Plasma levels and urinary excretion of other mineralocorticoids and glucocorticosteroids were low or normal. Urinary tetrahydrocortisol (THF) was increased relative to tetrahydrocortisone (THE) and also the plasma cortisol to cortisone ratio was elevated. These findings are suggestive of a decreased activity of cortisol-11β-hydroxysteroid dehydrogenase. Hypertension and hypokalaemia were not influenced by spironolactone and dexamethasone. Triamterene normalised serum potassium, but addition of furosemide was required for lowering blood pressure. With this treatment catch-up growth was observed.
© 1982 S. Karger AG, Basel
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Article / Publication Details
Published online: November 25, 2008
Issue release date: 1982
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: https://www.karger.com/HRP
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