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Report

Ketoconazole Shampoo: Effect of Long-Term Use in Androgenic Alopecia

Piérard-Franchimont C.a · De Doncker P.b · Cauwenbergh G.c · Piérard G.E.a

Author affiliations

aDepartment of Dermatopathology, University of Liège, and bJanssen Research Foundation, Beerse, Belgium; cJohnson and Johnson Research and Development, Skillman, N.J., USA

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Dermatology 1998;196:474–477

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Article / Publication Details

First-Page Preview
Abstract of Report

Published online: June 26, 1998
Issue release date: 1998

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM

Abstract

Background: The pathogenesis of androgenic alopecia is not fully understood. A microbial-driven inflammatory reaction abutting on the hair follicles might participate in the hair status anomaly. Objective: The aim of our study was to determine if ketoconazole (KCZ) which is active against the scalp microflora and shows some intrinsic anti-inflammatory activity might improve alopecia. Method: The effect of 2% KCZ shampoo was compared to that of an unmedicated shampoo used in combination with or without 2% minoxidil therapy. Results: Hair density and size and proportion of anagen follicles were improved almost similarly by both KCZ and minoxidil regimens. The sebum casual level appeared to be decreased by KCZ. Conclusion: Comparative data suggest that there may be a significant action of KCZ upon the course of androgenic alopecia and that Malassezia spp. may play a role in the inflammatory reaction. The clinical significance of the results awaits further controlled study in a larger group of subjects.


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    External Resources
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Article / Publication Details

First-Page Preview
Abstract of Report

Published online: June 26, 1998
Issue release date: 1998

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM


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